RT Journal Article
T1 Addition of Olive Leaf Extract to a Mixture of Algae and Extra Virgin Olive Oils Decreases Fatty Acid Oxidation and Synergically Attenuates Age-Induced Hypertension, Sarcopenia and Insulin Resistance in Rats
A1 González Hedström, Daniel
A1 Fuente Fernández, María De La
A1 Priego Cuadra, Teresa
A1 Martín Velasco, Ana Isabel
A1 Amor, Sara
A1 López-Calderón Barreda, Asunción
A1 Inarejos García, Antonio Manuel
A1 García Villalón, Ángel Luís
A1 Granado, Miriam
AB Olive-derived products, such as virgin olive oil (EVOO) and/or olive leaf extracts (OLE), exert anti-inflammatory, insulin-sensitizing and antihypertensive properties and may be useful for stabilizing omega 3 fatty acids (n-3 PUFA) due to their high content in antioxidant compounds. In this study, the addition of OLE 4:0.15 (w/w) to a mixture of algae oil (AO) rich in n-3 PUFA and EVOO (25:75, w/w) prevents peroxides formation after 12 months of storage at 30 °C. Furthermore, the treatment with the oil mixture (2.5 mL/Kg) and OLE (100 mg/Kg) to 24 month old Wistar rats for 21 days improved the lipid profile, increased the HOMA-IR and decreased the serum levels of miRNAs 21 and 146a. Treatment with this new nutraceutical also prevented age-induced insulin resistance in the liver, gastrocnemius and visceral adipose tissue by decreasing the mRNA levels of inflammatory and oxidative stress markers. Oil mixture + OLE also attenuated the age-induced alterations in vascular function and prevented muscle loss by decreasing the expression of sarcopenia-related markers. In conclusion, treatment with a new nutraceutical based on a mixture of EVOO, AO and OLE is a useful strategy for improving the stability of n-3 PUFA in the final product and to attenuate the cardiometabolic and muscular disorders associated with aging.
PB MPDI
SN 2076-3921
YR 2021
FD 2021-07-01
LK https://hdl.handle.net/20.500.14352/4871
UL https://hdl.handle.net/20.500.14352/4871
LA eng
NO González Hedström, D., Fuente Fernández, M., Priego Cuadra, T. et al. «Addition of Olive Leaf Extract to a Mixture of Algae and Extra Virgin Olive Oils Decreases Fatty Acid Oxidation and Synergically Attenuates Age-Induced Hypertension, Sarcopenia and Insulin Resistance in Rats». Antioxidants, vol. 10, n.o 7, julio de 2021, p. 1066. DOI.org (Crossref), https://doi.org/10.3390/antiox10071066.
NO Comunidad de Madrid
DS Docta Complutense
RD 9 abr 2025