TY  - JOUR
AU  - Ruiz-Pablos, Manuel
AU  - Paiva, Bruno
AU  - Zabaleta, Aintzane
PY  - 2025
DO  - 10.3389/fimmu.2025.1710571
SN  - 1664-3224
UR  - https://hdl.handle.net/20.500.14352/134027
AB  - The prevalence of autoimmune diseases in contemporary human populations poses a challenge for both medicine and evolutionary biology. This review explores how the ancestral human leukocyte antigen class II (HLA-II) haplotypes DR2-DQ6, DR4-DQ8 and...
LA  - eng
PB  - Frontiers Media
KW  - Autoimmunity
KW  - Hla class II
KW  - Drb1
KW  - Dqb1
KW  - Cytokines
KW  - Immune tolerance
KW  - Evolutionary genetics
KW  - Pathogen selection
TI  - The origin of autoimmune diseases: is there a role for ancestral HLA-II haplotypes in immune hyperactivity
TY  - journal article
VL  - 16
ER  -