RT Journal Article
T1 Engineering Mesoporous Silica Nanoparticles for Drug Delivery: where are we after two decades?
A1 Vallet Regí, María Dulce Nombre
A1 Schüth, Ferdi
A1 Lozano Borregón, Daniel
A1 Colilla Nieto, Montserrat
A1 Manzano García, Miguel
AB The present review details a chronological description of the events that took place during the development of mesoporous materials, their different synthetic routes and their use as drug delivery systems. The outstanding textural properties of these materials quickly inspired their translation to the nanoscale dimension leading to mesoporous silica nanoparticles (MSNs). The different aspects of introducing pharmaceutical agents into the pores of these nanocarriers, together with their possible biodistribution and clearance routes, would be here described. The development of smart nanocarriers able to release high local concentration of the therapeutic cargo on-demand after the application of certain stimuli would be here reviewed, together with the ability of delivering the therapeutic cargo to precise locations in the body. The huge progress in the design and development of MSNs for biomedical applications, including the potential treatment of different diseases, during the last 20 years will be here collected, together with the required work that still needs to be done to achieve the clinical translation of these materials. This review was conceived to stand out from past reports since aims to tell the story of the development of mesoporous materials and their use as drug delivery systems by some of the story makers, who could be considered to be among the pioneers in this area.
PB RSC
SN 0306-0012(Print) 1460-4744(Online)
YR 2022
FD 2022-06-01
LK https://hdl.handle.net/20.500.14352/72638
UL https://hdl.handle.net/20.500.14352/72638
LA eng
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón)ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)ORCID 0000-0003-1961-4160 (Montse Colilla Nieto)RESEARCHER ID K-3719-2014 (Miguel Manzano García)ORCID 0000-0001-6238-6111 (Miguel Manzano García)
NO Unión Europea. Horizonte 2020
NO Ministerio de Ciencia e Innovación (MICINN)
DS Docta Complutense
RD 2 may 2024