RT Journal Article
T1 External validation of a prognostic score to identify low-risk outpatients with acute deep venous thrombosis in the lower limbs
A1 Galeano Valle, Francisco
A1 Alonso Beato, Rubén
A1 Moragón Ledesma, Sergio
A1 Pire García, Tatiana
A1 Huergo Fernández, Olaya
A1 Ordieres Ortega, Lucía
A1 Oblitas, Crhistian Mario
A1 Álvarez-Sala Walther, Luis Antonio
A1 Demelo Rodríguez, Pablo
AB Background: Current clinical guidelines suggest home treatment for patients diagnosed with acute deep venous thrombosis (DVT). A prognostic score has been proposed to identify low-risk patients; however, its validation remains limited.Method: This prospective observational study aimed to externally validate the prognostic score in selecting low-risk outpatients with acute DVT in the lower limbs. Consecutive outpatients diagnosed with acute DVT in a tertiary hospital were included. The score included 6 variables: heart failure, kidney failure, recent major bleeding, altered platelet count, immobilization, and cancer. The primary outcome was the incidence of a composite outcome, including confirmed diagnosis of PE, major bleeding, or all-cause death at 7 days. Patients meeting zero criteria were considered low risk.Results: Among the 1035 patients included, 485 (46.9 %) met zero criteria. Of these, 0.2 % (95 % CI 0.0-1.1 %) and 0.4 % (95 % CI, 0.0-1.5 %) patients experienced the composite outcome at 7 and 30 days, respectively. Among patients who met 1 or more criteria for admission, 344 patients (62.5 %) were discharged. Among these, the composite outcome at 7 and 30 days occurred in 2 (0.6 %) and 5 (1.4 %) patients, respectively. The C-statistics of the score were 0.68 (95 % CI, 0.57-0.79) and 0.69 (95 % CI, 0.64-0.76) at 7 and 30 days, respectively.Conclusion: This study demonstrates the efficacy of the prognostic score in identifying low-risk outpatients with acute DVT. It also suggests that a considerable proportion of patients with acute DVT may benefit from outpatient treatment despite having some risk criteria, highlighting the potential for optimizing ambulatory care pathways.
PB Elsevier
SN 0953-6205
YR 2025
FD 2025-02
LK https://hdl.handle.net/20.500.14352/129316
UL https://hdl.handle.net/20.500.14352/129316
LA eng
NO Galeano-Valle F, Alonso-Beato R, Moragón-Ledesma S, Pire-García T, Huergo-Fernández O, Ordieres-Ortega L, Oblitas CM, Walther LAA, Demelo-Rodríguez P. External validation of a prognostic score to identify low-risk outpatients with acute deep venous thrombosis in the lower limbs. Eur J Intern Med. 2025 Feb;132:76-83. doi: 10.1016/j.ejim.2024.10.007. Epub 2024 Oct 15. PMID: 39406608.
DS Docta Complutense
RD 30 dic 2025