RT Journal Article
T1 Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations
A1 Lifante Cañavate, José
A1 Shen, Yingli
A1 Zabala Gutiérrez, Irene
A1 Rubia Rodríguez, Irene
A1 Ortega, Daniel
A1 Fernández Monsalve, Nuria
A1 Melle Hernández, Sonia
A1 Granado García, Miriam
A1 Rubio Retama, Benito Jorge
A1 Jaque García, Daniel
A1 Ximendes, Erving Clayton
AB Luminescent nano‐thermometry is a fast‐developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high‐brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag2S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser‐induced hyperthermia. For that, a new procedure is designed in which thermal readout is obtained from the combination of in vivo transient thermometry measurements and in silico simulations. The synergy between in vivo and in silico measurements has made it possible to assess relevant numbers such as the efficiency of hyperthermia processes, the total heat energy deposited in the liver, and the relative contribution of Ag2S nanoparticles to liver heating. This work provides a new way for absolute thermal sensing of internal organs with potential application not only to hyperthermia processes but also to advanced diagnosis and therapy.
AB daniel.jaque@uam.es
PB Wiley-VCH GmbH
SN 2198-3844 (online)
YR 2021
FD 2021-03-03
LK https://hdl.handle.net/20.500.14352/7891
UL https://hdl.handle.net/20.500.14352/7891
LA eng
NO Lifante Cañavete, J., Shen, Y., Zabala Gutiérrez, I. et al. «Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag 2 S Nanothermometers and In Silico Simulations». Advanced Science, vol. 8, n.o 9, mayo de 2021, p. 2003838. DOI.org (Crossref), https://doi.org/10.1002/advs.202003838.
NO Online Version of Record before inclusion in an issue. Art. 2003838.Version of Record online: 03 March 2021Manuscript revised: 23 December 2020Manuscript received: 08 October 2020
NO Unión Europea. Horizonte 2020
NO Ministerio de Economía, Comercio y Empresa (España)
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Comunidad de Madrid
NO Instituto de Salud Carlos III
NO Centro de Excelencia Severo Ochoa
NO Hospital Universitario Ramón y Cajal
NO China Scholarship Council
DS Docta Complutense
RD 18 mar 2026