RT Journal Article
T1 Bistability and phase variation in Salmonella enterica
A1 García Pastor, Lucía
A1 Puerta-Fernández, Elena
A1 Casadesús, Josep
AB Cell-to-cell differences in bacterial gene expression can merely reflect the occurrence of noise. In certain cases, however, heterogeneous gene expression is a programmed event that results in bistable expression. If bistability is heritable, bacterial lineages are formed. When programmed bistability is reversible, the phenomenon is known as phase variation. In certain cases, bistability is controlled by genetic mechanisms (e. g., DNA rearrangement). In other cases, bistability has epigenetic origin. A robust epigenetic mechanism for the formation of bacterial lineages is the formation of heritable DNA methylation patterns. However, bistability can also arise upon propagation of gene expression patterns by feedback loops that are stable upon cell division. This review describes examples of bistability and phase variation in Salmonella enterica and discusses their adaptive value, sometimes in a speculative manner.
PB Elsevier
SN 1874-9399
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/98824
UL https://hdl.handle.net/20.500.14352/98824
LA eng
NO García-Pastor, Lucía, et al. «Bistability and Phase Variation in Salmonella Enterica». Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, vol. 1862, n.o 7, julio de 2019, pp. 752-58. https://doi.org/10.1016/j.bbagrm.2018.01.003.
NO Ministerio de Economía e Innovación (España)
NO European Commission
DS Docta Complutense
RD 24 dic 2025