RT Journal Article
T1 Osteogenic Effect of ZnO-Mesoporous Glasses loaded with Osteostatin
A1 Pérez, Rebeca
A1 Sánchez Salcedo, Sandra
A1 Lozano Borregón, Daniel
A1 Heras, Clara
A1 Esbrit, Pedro
A1 Vallet Regí, María Dulce Nombre
A1 Salinas Sánchez, Antonio Jesús
AB Mesoporous Bioactive Glasses (MBGs) are a family of bioceramics widely investigated for their putative clinical use as scaffolds for bone regeneration. Their outstanding textural properties determine high bioactivity when compared with other bioactive materials. Moreover, their great pore volumes allow these glasses to be loaded with a wide range of biomolecules to stimulate new bone formation. In this study, an MBG with composition, in mol-%, 80%SiO2–15%CaO–5%P2O5 (Blank, BL) was compared with two analogous glasses containing 4% and 5% of ZnO (4ZN and 5ZN) before and after impregnation with osteostatin, a C-terminal peptide from parathyroid hormone-related protein (PTHrP107-111). Zn2+ ions were included in the glass for their bone growth stimulator properties, whereas osteostatin was added by its osteogenic properties. Glasses were characterized, and their cytocompatibility investigated in pre-osteoblastic MC3T3-E1 cell cultures. The simultaneous additions of osteostatin and Zn2+ ions provoked enhanced MC3T3-E1 cell viability and higher differentiation capacity, compared with either raw BL or MBGs supplemented only with osteostatin or Zn2+. These in vitro results show that osteostatin enhances the osteogenic effect of Zn2+-enriched glasses, suggesting the potential of this combined approach in bone tissue engineering applications.
PB MDPI AG
SN 2079-4991
YR 2018
FD 2018-08-04
LK https://hdl.handle.net/20.500.14352/12227
UL https://hdl.handle.net/20.500.14352/12227
LA eng
NO Pérez, R., Sánchez Salcedo, S., Lozano Borregón, D. et al. «Osteogenic Effect of ZnO-Mesoporous Glasses Loaded with Osteostatin». Nanomaterials, vol. 8, n.o 8, agosto de 2018, p. 592. DOI.org (Crossref), https://doi.org/10.3390/nano8080592.
NO RESEARCHER ID N-4501-2014 (Sandra Sánchez Salcedo)ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo)RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón)ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID M-3316-2014 (Antonio Salinas Sánchez)ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)
NO Unión Europea. H2020
NO Ministerio de Economía, Comercio y Empresa (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 11 abr 2025