RT Journal Article
T1 A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action
A1 La Manna, Sara
A1 Di Natale, Concetta
A1 Panzetta, Valeria
A1 Leone, Marilisa
A1 Mercurio, Flavia
A1 Cipollone, Irene
A1 Monti, Maria
A1 Netti, Paolo
A1 Ferraro, Giarita
A1 Terán More, Aaron
A1 Sánchez Peláez, Ana Edilia
A1 Herrero Domínguez, Santiago
A1 Merlino, Antonello
A1 Marasco, Daniela
AB The physical and chemical properties of paddlewheel diruthenium compounds are highly dependent on the nature of the ligands surrounding the bimetallic core. Herein, we compare the ability of two diruthenium compounds, [Ru2Cl(D-p-FPhF)- (O2CCH3)3]·H2O (1) (D-p-FPhF− = N,N′-bis(4-fluorophenyl)- formamidinate) and K3[Ru2(O2CO)4]·3H2O (2), to act as inhibitors of amyloid aggregation of the Aβ1−42 peptide and its peculiar fragments, Aβ1−16 and Aβ21−40. A wide range of biophysical techniques has been used to determine the inhibition capacity against aggregation and the possible mechanism of action of these compounds (Thioflavin T fluorescence and autofluorescence assays, UV−vis absorption spectroscopy, circular dichroism, nuclear magnetic resonance, mass spectrometry, and electron scanning microscopy). Data show that the most effective inhibitory effect is shown for compound 1. This compound inhibits fiber formation and completely abolishes the cytotoxicity of Aβ1−42. The antiaggregatory capacity of this complex can be explained by a binding mechanism of the dimetallic units to the peptide chain along with π−π interactions between the formamidinate ligand and the aromatic side chains. The results suggest the potential use of paddlewheel diruthenium complexes as neurodrugs and confirm the importance of the steric and charge effects on the properties of diruthenium compounds
PB American Chemical Society
SN 0020-1669
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/93172
UL https://hdl.handle.net/20.500.14352/93172
LA eng
NO Sara La Manna, Concetta Di Natale, Valeria Panzetta, Marilisa Leone, Flavia A. Mercurio, Irene Cipollone, Maria Monti, Paolo A. Netti, Giarita Ferraro, Aarón Terán, Ana E. Sánchez-Peláez, Santiago Herrero, Antonello Merlino, and Daniela MarascoInorganic Chemistry 2024 63 (1), 564-575DOI: 10.1021/acs.inorgchem.3c03441
NO Universidad Complutense de Madrid
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 8 abr 2025