RT Journal Article
T1 Neonicotinoids: Mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage
A1 Xu, X
A1 Wang, X
A1 Yang, Y
A1 Ares Lombán, Irma
A1 Martínez Caballero, Marta
A1 López Torres, Bernardo
A1 Martínez Larrañaga, María Rosa
A1 Wang, X
A1 Anadón Navarro, Arturo Ramón
A1 Martínez Caballero, María Aranzazu
AB Neonicotinoids are the most widely used pesticides in the world. However, research studies have shown that it can affect the cognitive abilities and health of non-target bees and other wild pollinators by inducing DNA damage, apoptosis and mitochondrial damage, injure to its central nervous system, and it is even developmentally neurotoxic to mammals and humans, with mitochondria being an important target of neonicotinoids. Therefore, this article reviews the role of mitochondrial morphology, calcium ions (Ca2+) homeostasis, respiratory function, apoptosis, and DNA damage in neonicotinoids-induced systemic toxicity. Additionally, it evaluates the protective effects of various active substances including vitamin C, N-acetylcysteine (NAC), curcumin (CUR), glutathione reduced (GSH), caffeic acid phenethyl ester (CAPE), resveratrol, and thymoquinone (TQ) on neonicotinoids-induced toxicity. This review manuscript found that mitochondria are important targets to neonicotinoids. Neonicotinoids can cause DNA damage, apoptosis, protein oxidation, and lipid peroxidation in non-target organisms by altering mitochondrial Ca2+ homeostasis, inhibiting mitochondrial respiration, and inducing reactive oxygen species (ROS) production. Several active substances (vitamin C, NAC, CUR, GSH, resveratrol, CAPE, and TQ) play a protective role against neonicotinoid-induced systemic toxicity by inhibiting ROS signaling pathways, apoptosis, and lipid peroxidation. This review manuscript emphasizes the importance and urgency of the development of neonicotinoid antidotes, emphasizes the prospect of the application of targeted mitochondrial antidotes, and prospects the development of neonicotinoid antidotes in order to provide some strategies for the prevention of neonicotinoid toxicity.
PB Springer nature
SN 0340-5761
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/138675
UL https://hdl.handle.net/20.500.14352/138675
LA eng
NO Xu, X., Wang, X., Yang, Y., Ares, I., Martínez, M., Lopez-Torres, B., Martínez-Larrañaga, M. R., Wang, X., Anadón, A., & Martinez, M. A. (2022). Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage. Archives of toxicology, 96(6), 1493–1520. https://doi.org/10.1007/s00204-022-03267-5
NO Universities of China
NO Ministerio de Ciencia, Innovación y Universidades ( España)
DS Docta Complutense
RD 20 ago 2026