RT Journal Article T1 Cardiac System during the Aging Process A1 Fernandes Ribeiro, Ana SofĂ­a A1 Egea Zerolo, Blanca A1 Lopez-Espuela, Fidel A1 Sanchez, Raul A1 Leite Fernandes, Vitor Samuel AB The aging process is accompanied by a continuous decline of the cardiac system, disrupting the homeostatic regulation of cells, organs, and systems. Aging increases the prevalence of cardiovascular diseases, thus heart failure and mortality. Understanding the cardiac aging process is of pivotal importance once it allows us to design strategies to prevent age-related cardiac events and increasing the quality of live in the elderly. In this review we provide an overview of the cardiac aging process focus on the following topics: cardiac structural and functional modifications; cellular mechanisms of cardiac dysfunction in the aging; genetics and epigenetics in the development of cardiac diseases; and aging heart and response to the exercise. PB California : JKL International SN 2152-5250 YR 2023 FD 2023 LK https://hdl.handle.net/20.500.14352/94028 UL https://hdl.handle.net/20.500.14352/94028 LA eng NO Ribeiro ASF, Zerolo BE, Lopez-Espuela F, Sanchez R, Fernandes VS. Cardiac System during the Aging Process. Aging and Disease 2023:0. https://doi.org/10.14336/AD.2023.0115. DS Docta Complutense RD 22 dic 2025