%0 Journal Article
%A Valencia Calvo, Marta
%A Durán Merinero, Alba
%A Lorenzo Aparicio, María Del Carmen
%A Gómez Gallego, María Del Mar
%A Sierra Rodríguez, Miguel Ángel
%A Eguillor, Beatriz
%A Esteruelas Rodrigo, Miguel Ángel
%A Oliván Escó, Montserrat
%A Oñate, Enrique
%T Osmium-promoted σ‑bond activation reactions on nucleosides
%D 2020
%@ 0276-7333
%U https://hdl.handle.net/20.500.14352/110690
%X OsH6(PiPr3)2 has been used to selectively activate C−H, O−H, and C−C sigma bonds in nucleobases and nucleosides, including derivatives of6-phenylpurine and 4-phenylpyrimidine, leading to cyclometalated mononuclear Os−trihydride complexes, in excellent yields and as single products.Additionally, OsH6(PiPr3)2 promotes the efficient dehydrogenative decarbonylation of primary alcohols in nucleosides having unprotected sugar moieties.The incorporation of OsH2Cl2(PiPr3)2 in the structure of cyclometalated Ir(III) and Rh(III) half-sandwich complexes derived from nucleosides allows the preparation of a class of heterobimetallic bioorganometallic complexes having at least one M−C bond. These methodologies could be used in thefuture as a way for the orthogonal functionalization of oligonucleotides
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