RT Journal Article
T1 Osmium-promoted σ‑bond activation reactions on nucleosides
A1 Valencia Calvo, Marta
A1 Durán Merinero, Alba
A1 Lorenzo Aparicio, María Del Carmen
A1 Gómez Gallego, María Del Mar
A1 Sierra Rodríguez, Miguel Ángel
A1 Eguillor, Beatriz
A1 Esteruelas Rodrigo, Miguel Ángel
A1 Oliván Escó, Montserrat
A1 Oñate, Enrique
AB OsH6(PiPr3)2 has been used to selectively activate C−H, O−H, and C−C sigma bonds in nucleobases and nucleosides, including derivatives of6-phenylpurine and 4-phenylpyrimidine, leading to cyclometalated mononuclear Os−trihydride complexes, in excellent yields and as single products.Additionally, OsH6(PiPr3)2 promotes the efficient dehydrogenative decarbonylation of primary alcohols in nucleosides having unprotected sugar moieties.The incorporation of OsH2Cl2(PiPr3)2 in the structure of cyclometalated Ir(III) and Rh(III) half-sandwich complexes derived from nucleosides allows the preparation of a class of heterobimetallic bioorganometallic complexes having at least one M−C bond. These methodologies could be used in thefuture as a way for the orthogonal functionalization of oligonucleotides
PB ACS
SN 0276-7333
YR 2020
FD 2020-01-15
LK https://hdl.handle.net/20.500.14352/110690
UL https://hdl.handle.net/20.500.14352/110690
LA eng
NO Organometallics 2020, 39, 312−323
NO Ministerio de Ciencia e Innovación
NO Fundación Ramón Areces
NO Gobierno de Aragón
DS Docta Complutense
RD 8 abr 2025