RT Journal Article
T1 Metabolomic Profiling, Antioxidant and Enzyme Inhibition Properties and Molecular Docking Analysis of Antarctic Lichens
A1 Torres-Benítez, Alfredo
A1 Ortega-Valencia, José Erick
A1 Sánchez Gómez-Serranillos, Marta
A1 Dulare Devi, Pradeep Divakar
A1 Simirgiotis; Mario J., 
A1 Gómez-Serranillos Cuadrado, María Pilar
AB The lichen species Lecania brialmontii, Pseudephebe pubescens, and Sphaerophorus globosus are part of the prominent lichenoflora of the Antarctic territory. In this work, we report the metabolomic identification of ethanolic extracts of these species, their antioxidant and cholinesterase enzyme inhibitory activity, and conduct a molecular docking analysis with typical compounds. Eighteen compounds were identified by UHPLC-ESI-QTOF-MS in L. brialmontii, 18 compounds in P. pubescens, and 14 compounds in S. globosus. The content of phenolic compounds was variable among the species, ranging from 0.279 to 2.821 mg AG/g, and all three species showed high inhibition potential on the cholinesterase enzymes. Molecular docking showed important interactions between AChE and BChE with the selected compounds. This study evidences the chemical fingerprint of three species of the order Lecanorales that support the continuation of the study of other biological activities and their potential for medical research.
PB MDPI
YR 2022
FD 2022-11-21
LK https://hdl.handle.net/20.500.14352/125053
UL https://hdl.handle.net/20.500.14352/125053
LA eng
NO Torres-Benítez A, Ortega-Valencia JE, Sanchez M, Divakar PK, Simirgiotis MJ, Gómez-Serranillos MP. Metabolomic Profiling, Antioxidant and Enzyme Inhibition Properties and Molecular Docking Analysis of Antarctic Lichens. Molecules 2022;27:8086. https://doi.org/10.3390/molecules27228086.
NO Instituto Antártico Chileno
DS Docta Complutense
RD 18 oct 2025