RT Journal Article
T1 Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution
A1 Torres-Benítez, Alfredo
A1 Ortega-Valencia, José Erick
A1 Jara-Pinuer, Nicolás
A1 Sánchez Gómez-Serranillos, Marta
A1 Vargas-Arana, Gabriel
A1 Gómez-Serranillos Cuadrado, María Pilar
A1 Simirgiotis, Mario J.
AB The objective of this research was to characterize the chemical composition of ethanolic extracts of the lichen species Placopsis contortuplicata, Ochrolechia frigida, and Umbilicaria antarctica, their antioxidant activity, and enzymatic inhibition through in vitro and molecular docking analysis. In total phenol content, FRAP, ORAC, and DPPH assays, the extracts showed significant antioxidant activity, and in in vitro assays for the inhibition of pancreatic lipase, α-glucosidase, and α-amylase enzymes, together with in silico studies for the prediction of pharmacokinetic properties, toxicity risks, and intermolecular interactions of compounds, the extracts evidenced inhibitory potential. A total of 13 compounds were identified by UHPLC-ESI-QTOF-MS in P. contortuplicata, 18 compounds in O. frigida, and 12 compounds in U. antarctica. This study contributes to the knowledge of the pool of bioactive compounds present in lichens of temperate and polar distribution and biological characteristics that increase interest in the discovery of natural products that offer alternatives for treatment studies of diseases related to oxidative stress and metabolic syndrome.
SN 1663-9812
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/96896
UL https://hdl.handle.net/20.500.14352/96896
LA eng
NO Instituto Antártico Chileno
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Agencia Nacional de Investigación y Desarrollo (Chile)
DS Docta Complutense
RD 7 abr 2025