RT Journal Article
T1 Alpha lipoic acid efficacy in burning mouth syndrome: a controlled clinical trial
A1 Palacios-Sánchez, Begoña
A1 Moreno López, Luis Alberto
A1 Cerero Lapiedra, Rocío
A1 Llamas-Martínez, Silvia
A1 Esparza Gómez, Germán Carlos
AB Background: A double-blind placebo-controlled trial was conducted in order to evaluate the efficacy of alpha lipoic acid (ALA) and determine the statistical significance of the outcome variables. Burning mouth syndrome (BMS) is defined as an oral burning sensation in the absence of clinical signs which could justify the syndrome. Recent studies suggest the existence of neurological factors as a possible cause of the disease.Material and methods: 60 patients with BMS, in two groups: case group with 600 mg/day and placebo as control group; with follow up of 2 months.Results: 64% of ALA patients reported some level of improvement, with a level of maintenance of 68.75% one month after treatment. 27.6% of the placebo group also demonstrated some reduction in BMS symptoms.Conclusions: Long-term evolution and the intensity of symptoms are variables that reduce the probability of improvement with ALA treatment.
PB Medicina Oral
SN 1698-4447
YR 2015
FD 2015-06-02
LK https://hdl.handle.net/20.500.14352/116534
UL https://hdl.handle.net/20.500.14352/116534
LA eng
NO Palacios-Sánchez B, Moreno-López LA, Cerero-Lapiedra R, Llamas-Martínez S, Esparza-Gómez G. Alpha lipoic acid efficacy in burning mouth syndrome. A controlled clinical trial. Med Oral Patol Oral Cir Bucal. 2015 Jul 1;20(4):e435-40. doi: 10.4317/medoral.20410
DS Docta Complutense
RD 8 abr 2025