RT Journal Article
T1 Mesoporous bioactive glass/ɛ-polycaprolactone scaffolds promote bone regenerationin osteoporotic sheep
A1 Gómez Cerezo, María Natividad
A1 Casarrubios Molina, Laura
A1 Saiz-Pardo, M.
A1 Ortega, L.
A1 De Pablo, D.
A1 Díaz-Güemes, I.
A1 Fernández-Tomé, E.
A1 Enciso, S
A1 Sanchez-Margallo, F. M.
A1 Portolés Pérez, María Teresa
A1 Arcos Navarrete, Daniel
A1 Vallet Regí, María Dulce Nombre
AB Macroporous scaffolds made of a SiO2-CaO-P2O5 mesoporous bioactive glass (MBG) and ɛpolycaprolactone (PCL) have been prepared by robocasting. These scaffolds showed an excellent in vitro biocompatibility in contact with osteoblast like cells (Saos 2) and osteoclasts derived from RAW 264.7 macrophages. In vivo studies were carried out by implantation into cavitary defects drilled in osteoporotic sheep. The scaffolds evidenced excellent bone regeneration properties, promoting new bone formation at both the peripheral and the inner parts of the scaffolds, thick trabeculae, high vascularization and high presence of osteoblasts and osteoclasts. In order to evaluate the effects of the local release of an antiosteoporotic drug, 1% (%wt) of zoledronic acid was incorporated to the scaffolds. The scaffolds loaded with zoledronic acid induced apoptosis in Saos 2 cells, impeded osteoclast differentiation in a time dependent manner and inhibited bone healing, promoting an intense inflammatory response in osteoporotic sheep.
PB Elsevier
SN 1742-7061
YR 2019
FD 2019-04-05
LK https://hdl.handle.net/20.500.14352/13221
UL https://hdl.handle.net/20.500.14352/13221
LA eng
NO RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 24 ago 2024