%0 Journal Article
%A Alicia Galar
%A Valerio Minero, Maricela
%A Muñoz García, Patricia Carmen
%A Alcalá, Luis 
%A García-González, Xandra 
%A Burillo Albizua, Almudena
%A Sanjurjo, María 
%A Grau, Santiago 
%A Bouza Santiago, Emilio
%T Systematic Therapeutic Drug Monitoring for Linezolid: Variability and Clinical Impact
%D 2017
%@ 0066-4804
%@ 1098-6596
%U https://hdl.handle.net/20.500.14352/116861
%X Linezolid serum trough (Cmin) and peak (Cmax) levels were determined prospectively in 90 patients. Adequate exposure was defined as a Cmin of 2 to 8 mg/liter. Therapy was empirical (73.3%) or targeted (26.7%). Wide interindividual variability in linezolid Cmin levels was recorded (0.1 to 25.2 μg/ml). Overall, 65.5% of the patients had out-of-range, 41.1% had subtherapeutic, and 24.4% had supratherapeutic trough levels. We did not find a correlation between abnormal levels and adverse events, in-hospital mortality, or overall poor outcome.
%~