RT Journal Article
T1 e14a2 Transcript Favors Treatment-Free Remission in Chronic Myeloid Leukemia When Associated with Longer Treatment with Tyrosine Kinase Inhibitors and Sustained Deep Molecular Response
A1 Marcé, Sílvia
A1 Escribano Serrat, Silvia
A1 Anguita Mandly, Eduardo Luis
A1 Zamora, Lurdes
AB e13a2 and e14a2 are the most frequent transcript types of the BCR::ABL1 fusion gene in chronic myeloid leukemia (CML). The current goal with tyrosine kinase inhibitors (TKI) is to achieve sustained deep molecular response (DMR) in order to discontinue TKI treatment and remain in the so-called treatment-free remission (TFR) phase, but biological factors associated with these goals are not well established. This study aimed to determine the effect of transcript type on TFR in patients receiving frontline treatment with imatinib (IM) or second-generation TKI (2G-TKI). Patients treated at least 119 months with IM presented less post-discontinuation relapse than those that discontinued IM before 119 months (p = 0.005). In addition, cases with the e14a2 transcript type treated at least 119 months with IM presented a better TFR (p = 0.024). On the other hand, the type of transcript did not affect the cytogenetic or molecular response in 2G-TKI treated patients; however, the use of 2G-TKI may be associated with higher and earlier DMR in patients with the e14a2 transcript.
PB MDPI
SN 2077-0383
YR 2024
FD 2024-01-29
LK https://hdl.handle.net/20.500.14352/105332
UL https://hdl.handle.net/20.500.14352/105332
LA eng
NO Marcé S, Méndez A, Xicoy B, Estrada N, Cabezón M, Sturla AL, García MR, Angona A, Amat P, Escribano Serrat S, et al. e14a2 Transcript Favors Treatment-Free Remission in Chronic Myeloid Leukemia When Associated with Longer Treatment with Tyrosine Kinase Inhibitors and Sustained Deep Molecular Response. Journal of Clinical Medicine. 2024; 13(3):779. https://doi.org/10.3390/jcm13030779
NO Generalitat de Catalunya
NO Josep Carreras International Foundation
NO “La Caixa” Foundation
DS Docta Complutense
RD 20 ago 2024