RT Journal Article
T1 A multivariate model of time to conversion from mild cognitive impairment to Alzheimer’s disease
A1 López García, María Eugenia
A1 Turrero Nogués, Agustín
A1 Cuesta Prieto, Pablo
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Barabash Bustelo, Ana
A1 Marcos Dolado, Alberto
A1 Maestu Unturbe, Fernando
A1 Fernández Lucas, Alberto Amable
AB The present study was aimed at determining which combination of demographic, genetic, cognitive, neurophysiological, and neuroanatomical factors may predict differences in time to progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD). To this end, a sample of 121 MCIs was followed up during a 5-year period. According to their clinicaloutcome, MCIs were divided into two subgroups: (i) the “progressive” MCI group (n = 46; mean time to progression 17 ± 9.73 months) and (ii) the “stable” MCIgroup (n = 75; mean time of follow-up 31.37 ± 14.58 months). Kaplan–Meier survival analyses were applied to explore each variable’s relationship with the progression to AD. Once potential predictors were detected, Cox regression analyses were utilized to calculate a parsimonious model to estimate differences in time to progression. The final model included three variables (in order of relevance): left parahippocampal volume (corrected by intracranial volume, LP_ ICV), delayed recall (DR), and left inferior occipital lobe individual alpha peak frequency (LIOL_IAPF). Those MCIs with LP_ICV volume, DR score, and LIOL_IAPF value lower than the defined cutoff had 6 times, 5.5 times, and 3 times higher risk of progression to AD, respectively. Besides, when the categories of the three variables were “unfavorable” (i.e., values below the cutoff), 100% of cases progressed to AD at the end of follow-up. Our results highlighted the relevance of neurophysiological markers as predictors of conversion (LIOL_IAPF) and the importance of multivariate models that combine markers of different nature topredict time to progression from MCI to dementia.
PB Springer
SN 2509-2715
SN 2509-2723
YR 2020
FD 2020-09-04
LK https://hdl.handle.net/20.500.14352/91801
UL https://hdl.handle.net/20.500.14352/91801
LA eng
DS Docta Complutense
RD 17 ago 2024