RT Journal Article
T1 Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy
A1 del Cerro-León, Alberto
A1 Antón Toro, Luis Fernando
A1 Shpakivska-­ Bilan, Danylyna
A1 Uceta, Marcos
A1 Santos Mayo, Alejandro
A1 Cuesta Prieto, Pablo
A1 Bruña Fernández, Ricardo
A1 García Moreno, Luis Miguel
A1 Maestu Unturbe, Fernando
AB Alcohol consumption during adolescence has been associated with neuroanatomical abnormalities and the appearance of future disorders. However, the latest advances in this field point to the existence of risk profiles which may lead to some individuals into an early consumption. To date, some studies have established predictive models of consumption based on sociodemographic, behavioral, and anatomical–functional variables using MRI. However, the neuroimaging variables employed are usually restricted to local and hemodynamic phenomena. Given the potential of connectome approaches, and the high temporal dynamics of electrophysiology, we decided to explore the relationship between future alcohol consumption and electrophysiological connectivity measured by MEG in a cohort of 83 individuals aged 14 to 16. As a result, we found a positive correlation between alcohol consumption and the functional connectivity in frontal, parietal, and frontoparietal connections. Once this relationship was described, multivariate linear regression analyses were used to evaluate the predictive capacity of functional connectivity in conjunction with other neuroanatomical and behavioral variables described in the literature. Finally, the multivariate linear regression analysis determined the importance of anatomical and functional variables in the prediction of alcohol consumption but failed to find associations with impulsivity, sensation seeking, and executive function scales. In conclusion, the predictive traits obtained in these models were closely associated with changes occurring during adolescence, suggesting the existence of different paths in neurodevelopment that have the potential to influence adolescents’ relationship with alcohol consumption.
PB Washington, D.C. National Academy of Sciences
SN 0027-8424
YR 2024
FD 2024-10-08
LK https://hdl.handle.net/20.500.14352/110375
UL https://hdl.handle.net/20.500.14352/110375
LA eng
NO Del Cerro-León, A., Fernando Antón-Toro, L., Shpakivska-Bilan, D., Uceta, M., Santos-Mayo, A., Cuesta, P., Bruña, R., García-Moreno, L. M., & Maestú, F. (2024). Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy. Proceedings of the National Academy of Sciences of the United States of America, 121(42), e2320805121. https://doi.org/10.1073/pnas.2320805121
NO Acceso restringido hasta el 8 de abril de 2025
NO Ministerio de Sanidad (España)
DS Docta Complutense
RD 6 abr 2025