RT Journal Article
T1 Porphyria cutanea tarda as a Predictor of Poor Response to Interferon Alfa Therapy in Chronic Hepatitis C
A1 Fernández Vázquez, María Inmaculada
A1 Castellano Tortajada, Gregorio
A1 De Salamanca, R. E.
A1 Colina Ruiz-Delgado, Francisco
A1 Gómez De La Cámara, Agustín Ramón
A1 Morán, M. J.
A1 Muñoz, R.
A1 Solís Herruzo, José Antonio
AB Background: Porphyria cutanea tarda (PCT) is sometimes associated with hepatitis C virus chronic infection. The aim of this study was to describe the effect of interferon alfa (IFN-a) in the treatment of patients with chronic hepatitis C and PCT.Methods: We treated a total of 66 patients with chronic hepatitis C with IFN-a 2b (5 MU t.i.w.) for 12 months. Twenty-two of these patients suffered from PCT as well. These patients differed from patients without PCT in that they were men, past history of alcohol abuse and HFE gene mutations were more common and the source of infection was almost always unknown.Results: Sustained virologie response was obtained in 19.7% of the 66 treated patients, 27.3% in the non-PCT group and 4.5% in the PCT group (P < 0.05). This difference could not be ascribed to the difference in sex of patients, history of alcohol abuse, HCV genotype or iron status.Conclusion: Multivariate logistic regression analysis revealed that PCT is independently and significantly associated with non-sustained response to IFNa therapy. In conclusion, patients with chronic hepatitis C and PCT rarely responded to IFNa treatment.
PB Taylor and Francis
SN 0036-5521
YR 2003
FD 2003-01
LK https://hdl.handle.net/20.500.14352/113898
UL https://hdl.handle.net/20.500.14352/113898
LA eng
NO Fernández I, Castellano G, de Salamanca RE, Colina F, de la Cámara AG, Morán MJ, Muñoz R, Solís-Herruzo JA. Porphyria cutanea tarda as a Predictor of Poor Response to Interferon Alfa Therapy in Chronic Hepatitis C. Scand J Gastroenterol. 2003 Mar;38(3):314-319. doi: 10.1080/00365520310000672a.
NO Instituto de Salud Carlos III (España)
DS Docta Complutense
RD 12 abr 2025