RT Journal Article
T1 Programmed versus non-programmed evolution of aging. What is the evidence?
A1 Pamplona, Reinald
A1 Jové, Mariona
A1 Gómez, José
A1 Barja De Quiroga Losada, Gustavo
AB The evolutionary meaning and basic molecular mechanisms involved in the determination of longevity remain an unresolved problem. Currently, different theories are on offer in response to these biological traits and to explain the enormous range of longevities observed in the animal kingdom. These theories may be grouped into those that defend non-programmed aging (non-PA) and those that propose the existence of programmed aging (PA). In the present article we examine many observational and experimental data from both the field and from the laboratory and sound reasoning accumulated in recent decades both compatible and not with PA and non-PA evolutionary theories of aging. These analyses are briefly summarized and discussed. Our conclusion is that most of the data favour programmed aging with a possible contribution of non-PA antagonist pleiotropy in various cases.
PB Elsevier
SN 0531-5565
YR 2023
FD 2023-05
LK https://hdl.handle.net/20.500.14352/122483
UL https://hdl.handle.net/20.500.14352/122483
LA eng
NO Pamplona, R., Jové, M., Gómez, J., & Barja, G. (2023). Programmed versus non-programmed evolution of aging. What is the evidence? [Review of Programmed versus non-programmed evolution of aging. What is the evidence?]. Experimental Gerontology, 175. Elsevier Inc. https://doi.org/10.1016/J.EXGER.2023.112162
NO The authors were supported by the Spanish Ministry of Science and Innovation, the Autonomous Government of the Community of Madrid, and the Generalitat of Catalonia (2021SGR00990). Mariona Jové is a “Serra Hunter” Fellow.
NO Ministerio de Ciencia e Innovación (España)
NO Comunidad de Madrid
NO Generalitat de Catalunya
DS Docta Complutense
RD 18 dic 2025