RT Generic T1 Análisis de mediadores inflamatorios en plasma y encía de ratas con periodontitis y depresión. A1 Cuba Mamani, Eber Asbel AB CONCLUSIONES- La periodontitis y la depresión presentaron concentraciones de mediadores inflamatorios tanto en encía como en plasma, lo que sugiere vincular un posible mecanismo en la etiopatogénesis entre estas dos patologías.- Los niveles de mediadores inflamatorios en encía producidos en el grupo (P+CMS+) fueron estadísticamente iguales que los producidos en los grupos (P+CMS-), (P�CMS+) y (P-CMS-).- Los niveles de mediadores inflamatorios en plasma producidos en el grupo (P+CMS+) fueron estadísticamente mayores que los producidos en los grupos (P+CMS-), (P-CMS+) y (P-CMS-). YR 2021 FD 2021 LK https://hdl.handle.net/20.500.14352/9257 UL https://hdl.handle.net/20.500.14352/9257 LA spa NO - Arauchi, R., Hashioka, S., Tsuchie, K., Miyaoka, T., Tsumori, T., Limoa, E., Azis, I. A., Ohnishi, A., Miura, S., Otsuki, K., Kanayama, M., Izuhara, M., Nagahama, M., Kawano, K., Araki, T., Liaury, K., Abdullah, R. A., Wake, R., Hayashida, M., … Horiguchi, J. (2018). Gunn rats with glial activation in the hippocampus show prolonged immobility time in the forced swimming test and tail suspension test. May, 1–9. https://doi.org/10.1002/brb3.1028 - Araújo, M. M., Martins, C. C., Costa, L. C. M., Cota, L. O. M., Faria, R. L. A. M., Cunha, F. A., & Costa, F. O. (2016). Association between depression and periodontitis: A systematic review and meta-analysis. Journal of Clinical Periodontology, 43(3), 216–228. https://doi.org/10.1111/jcpe.12510 - Breivik, T., Gundersen, Y., Murison, R., Turner, J. D., Muller, C. P., Gjermo, P., & Opstad, K. (2015). Maternal Deprivation of Lewis Rat Pups Increases the Severity of Experi-mental Periodontitis in Adulthood. The Open Dentistry Journal, 9(1), 65–78. https://doi.org/10.2174/1874210601509010065 - Buduneli, N., & Kinane, D. F. (2011). Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis. Journal of Clinical Periodontology, 38, 85–105. https://doi.org/10.1111/j.1600-051X.2010.01670.x - Carasol, M., Llodra, J. C., Fernández-Meseguer, A., Bravo, M., García-Margallo, M. T., Calvo-Bonacho, E., Sanz, M., & Herrera, D. (2016). Periodontal conditions among employed adults in Spain. Journal of Clinical Periodontology, 43(7), 548–556. https://doi.org/10.1111/jcpe.12558 - Carolina, N., Offenbacher, S., Carolina, N., & Hill, C. (1996). Periodontal Diseases : Pathogenesis. 1(1), 821–878. - Caton, J. G., Armitage, G., Berglundh, T., Chapple, I. L. C., Jepsen, S., Kornman, K. S., Mealey, B. L., Papapanou, P. N., Sanz, M., & Tonetti, M. S. (2018). A new classification scheme for periodontal and peri ‐ implant diseases and conditions – Introduction and key changes from the 1999 classification. 45(March), 1–8. https://doi.org/10.1111/jcpe.12935 - Chapple, I. L. C., Mealey, B. L., Dyke, T. E. Van, Bartold, P. M., Dommisch, H., Eickholz, P., Geisinger, M. L., Genco, R. J., Glogauer, M., Goldstein, M., Griffin, T. J., Holmstrup, P., 39 Johnson, G. K., Kapila, Y., Lang, N. P., & Meyle, J. (2018). Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium : Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri ‐ Implant Diseases and Conditions. 45(December 2017), 68–77. https://doi.org/10.1111/jcpe.12940 - Coelho, J. M. F., Miranda, S. S., da Cruz, S. S., dos Santos, D. N., Trindade, S. C., Cerqueira, E. de M. M., Passos-Soares, J. de S., Costa, M. da C. N., Figueiredo, A. C. M. G., Hintz, A. M., de Almeida, A. R. B., Pereira, M. N., de Souza, N. M., Barreto, M. L., & Gomes-Filho, I. S. (2020). Common mental disorder is associated with periodontitis. Journal of Periodontal Research, 55(2), 221–228. https://doi.org/10.1111/jre.12705 - Cota, M., & Costa, F. O. (2013). and Gestational Diabetes Mellitus : September, 1257–1265. https://doi.org/10.1902/jop.2012.120350 - Cunha, F. A., Cota, L. O. M., Cortelli, S. C., Miranda, T. B., Neves, F. S., Cortelli, J. R., & Costa, F. O. (2019). Periodontal condition and levels of bacteria associated with periodontitis in individuals with bipolar affective disorders: A case-control study. Journal of Periodontal Research, 54(1), 63–72. https://doi.org/10.1111/jre.12605 - Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010). A Meta-Analysis of Cytokines in Major Depression. BPS, 67(5), 446–457. https://doi.org/10.1016/j.biopsych.2009.09.033 - Dumitrescu, A. L. (2016). Depression and Inflammatory Periodontal Disease Considerations — An Interdisciplinary Approach. 7(March), 1–8. https://doi.org/10.3389/fpsyg.2016.00347 - Haffajee, S. S., Cugini, A. D., Smith, C., Jr, K., & Microbial, R. L. (1998). Microbial complexes in subgingival plaque. 134–144. - Hajishengallis, G. (2014). Immunomicrobial pathogenesis of periodontitis : keystones , pathobionts , and host response. Trends in Immunology, 35(1), 3–11. https://doi.org/10.1016/j.it.2013.09.001 - Hajishengallis, G., Lamont, R. J., & Graves, D. T. (2015) The enduring importance of animal models in understanding periodontal disease. Taylor & Francis. January 2015, 37–41. https://doi.org/10.4161/21505594.2014.990806 40 - Haro, J. M., Palacín, C., Vilagut, G., Martínez, M., Bernal, M., Alonso, G. E. J., Autonell, J., Bernal, M., Codony, M., Dolz, M., Palacín, C., Ramos, J., Reneses, B., Romera, B., Usall, J., & Vilagut, G. (2006). Prevalence of mental disorders and associated factors: results of the ESEMeD-Spain study. Medicina Clínica, 126(12), 445–451. https://doi.org/10.1157/13086324 - Hashioka, S., Inoue, K., Hayashida, M., Wake, R., Oh-Nishi, A., & Miyaoka, T. (2018). Implications of systemic inflammation and periodontitis for major depression. Frontiers in Neuroscience, 12(JUL), 1–7. https://doi.org/10.3389/fnins.2018.00483 - Hashioka, S., Inoue, K., Miyaoka, T., Hayashida, M., Wake, R., Oh-Nishi, A., & Inagaki, M. (2019). The possible causal link of periodontitis to neuropsychiatric disorders: More than psychosocial mechanisms. International Journal of Molecular Sciences, 20(15). https://doi.org/10.3390/ijms20153723 - Holtfreter, B., Kocher, T., Ko, J., & Kocher, T. (2010). Periodontal health in Europe : future trends based on treatment needs and the provision of periodontal services – position paper 1. 14(8), 4–24. https://doi.org/10.1111/j.1600-0579.2010.00620.x - Howren, B. M., Lamkin, D. M., & Suls, J. (2009). Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis. American Psychosomatic Society, 186(Il), 171– 186. https://doi.org/10.1097/PSY.0b013e3181907c1b - Hsu, C.-C., Hsu, Y.-C., Chen, H.-J., Lin, C.-C., Chang, K.-S., Lee, C.-Y., Chong, L.-W., & Kao, C.-H. (2015). Association of Periodontitis and Subsequent Depression. Medicine, 94(51), 1–6. https://doi.org/10.1097/MD.0000000000002347 - Huang, Y. K., Wang, Y. H., & Chang, Y. C. (2020). Chronic periodontitis is associated with the risk of bipolar disorder: A population-based cohort study. International Journal of Environmental Research and Public Health, 17(10). https://doi.org/10.3390/ijerph17103466 - Hwang, S. H., & Park, S. G. (2018). The relationship between depression and periodontal diseases. Community Dental Health, 35(1), 23–29. https://doi.org/10.1922/CDH_4150Hwang07 41 - Jepsen, S., Caton, J. G., Albandar, J. M., Bissada, N. F., Bouchard, P., Cortellini, P., Demirel, K., Sanctis, M. De, Ercoli, C., Fan, J., Geurs, N. C., Hughes, F. J., Matthews, D., Mcguire, M. K., Mills, M. P., & Preshaw, P. M. (2018). Periodontal manifestations of systemic diseases and developmental and acquired conditions : Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri ‐ Implant Diseases and Conditions. 45(February), 219–229. https://doi.org/10.1111/jcpe.12951 - Joëls, M., & Baram, T. Z. (2009). The neuro-symphony of stress. Nature reviews. Neuroscience, 10(6), 459–466. https://doi.org/10.1038/nrn2632 - Johannsen, A., Rydmark, I., Soder, B., & Asberg, M. (2007). Gingival inflammation , increased periodontal pocket depth and elevated interleukin-6 in gingival crevicular fluid of depressed women on long-term sick leave. Journal of Periodontal Research, 42, 546–552. https://doi.org/10.1111/j.1600-0765.2007.00980.x - Kassebaum, N. J., Bernabé, E., Dahiya, M., Bhandari, B., Murray, C. J., & Marcenes, W. (2014). Global Burden of Severe Tooth Loss: A Systematic Review and Meta-analysis. Journal of dental research, 93(7 Suppl), 20S–28S. https://doi.org/10.1177/0022034514537828 - Kohler, C., Freitas, T., Maes M, de A. N., Liu, C., Fernandes, B. S., Solmi, M., Veronese, N., Raison, C. L., Miller, B. J., Lanctot, K. L., & Carvalho, A. F. (2017). Peripheral cytokine and chemokine alterations in depression : a meta-analysis of 82 studies. Acta Psychiatrica Scandinavica, 135(5), 373–387. https://doi.org/10.1111/acps.12698 - Kornman, K. S. (1997). The pathogenesis of human periodontitis: an introduction. Periodontology 2000, 14, 9–11. https://doi.org/10.1111/j.1600- 0757.1997.tb00189.x - Kornman, K. S. (2008). Mapping the Pathogenesis of Periodontitis : A New Look. 79(8). https://doi.org/10.1902/jop.2008.080213 - Kuraji, R., Fujita, M., Ito, H., Hashimoto, S., & Numabe, Y. (2017). Effects of experimental periodontitis on the metabolic system in rats with diet ‐ induced obesity ( DIO ): an analysis of serum biochemical parameters. Odontology, 0123456789. https://doi.org/10.1007/s10266-017-0322-5 - Laforgia, A., Corsalini, M., Stefanachi, G., Pettini, F., & Di Venere, D. (2015). Assessment of 42 psychopatologic traits in a group of patients with adult chronic periodontitis: Study on 108 cases and analysis of compliance during and after periodontal treatment. International Journal of Medical Sciences, 12(10), 832–839. https://doi.org/10.7150/ijms.12317 - LeResche, L., & Dworkin, S. F. (2002). The role of stress in inflammatory disease, including periodontal disease: review of concepts and current findings. Periodontology 2000, 30, 91– 103. https://doi.org/10.1034/j.1600-0757.2002.03009.x - Liu, F., Wen, Y. F., Zhou, Y., Lei, G., Guo, Q. Y., & Dang, Y. H. (2018). A meta-analysis of emotional disorders as possible risk factors for chronic periodontitis. Medicine (United States), 97(28). https://doi.org/10.1097/MD.0000000000011434 - Lopresti, A. L., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014). Progress in Neuro-Psychopharmacology & Biological Psychiatry A review of peripheral biomarkers in major depression : The potential of in fl ammatory and oxidative stress biomarkers. Progress in Neuropsychopharmacology & Biological Psychiatry, 48, 102–111. https://doi.org/10.1016/j.pnpbp.2013.09.017 - Martín-Hernández, D., Caso, J. R., Bris, Á. G., Maus, S. R., José, L. M., García-Bueno, B., Macdowell, K. S., Alou, L., Gómez-Lus, M. L., & Leza, J. C. (2015). Bacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats. Neuropharmacology, 103, 122-133. https://doi.org/10.1016/j.neuropharm.2015.12.003 - Martínez, M., Martín-Hernández, D., Virto, L., Macdowell, K. S., González-Bris, A., Montero, E., Marín, M. J., Ambrosio, N., Herrera, D., Leza, J. C., Sanz, M., García-Bueno, B., Figuero, E., García-bueno, M. S. B., & Figuero, E. (2021). Periodontal diseases and depression : A pre-clinical in vivo study. Journal of Clinical Periodontology, 00(January), 1–25. https://doi.org/10.1111/jcpe.13420 - Martínez, M., Montero, E., Carasol, M., LLodrá, J. C., Sanz, M., Herrera, D., Calvo-Bonacho, E., Fernández-Meseguer, A., & Figuero, E. (2021). Association between caries and periodontal diseases in a sample of employed adults in Spain: a cross-sectional study. Clinical Oral Investigations, 25(6), 3957–3966. https://doi.org/10.1007/s00784-020- 03726-2 - Muniz, F. W. M. G., Melo, I. M., Rösing, C. K., de Andrade, G. M., Martins, R. S., Moreira, M. 43 M. S. M., & Carvalho, R. de S. (2018). Use of antidepressive agents as a possibility in the management of periodontal diseases: A systematic review of experimental studies. Journal of Investigative and Clinical Dentistry, 9(1), 1–6. https://doi.org/10.1111/jicd.12291 - Nascimento, G., Gastal, M. T., Leite, F. R., Quevedeo, K., Peres, M., Barros, F. C., & Dermarco, F. F. (2019). Key words: major depression, depressive symptoms, periodontal diseases, cohort studies. Journal of Clinical Periodontology, 46(31–39), 0–3. https://doi.org/10.1111/jcpe.13039 - Nayak, S. U., Singh, R., & Kota, K. P. (2016). Periodontal health among non-hospitalized chronic psychiatric patients in Mangaluru City-India. Journal of Clinical and Diagnostic Research, 10(8), ZC40–ZC43. https://doi.org/10.7860/JCDR/2016/19501.8248 - Oliveira, L. F. F., Salvador, S. L., Pharm, D., Silva, P. H. F., Furlaneto, F. A. C., & Figueiredo, L. (2016). Benefits of Bifidobacterium Animalis Subsp Lactis Probiotic in Experimental Periodontitis. Journal of Periodontology 1–20. https://doi.org/10.1902/jop.2016.160217 - Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., Flemmig, T. F., Garcia, R., Giannobile, W. V, Graziani, F., Greenwell, H., Herrera, D., Kao, R. T., Kebschull, M., Kinane, D. F., Kirkwood, K. L., Kocher, T., Kornman, K. S., Kumar, P. S., & Loos, B. G. (2018a). Periodontitis : Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri ‐ Implant Diseases and Conditions. 45(March), 162–170. https://doi.org/10.1111/jcpe.12946 - Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., Flemmig, T. F., Garcia, R., Giannobile, W. V, Graziani, F., Greenwell, H., Herrera, D., Kao, R. T., Kebschull, M., Kinane, D. F., Kirkwood, K. L., Kocher, T., Kornman, K. S., Kumar, P. S., & Loos, B. G. (2018b). Periodontitis : Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri ‐ Implant Diseases and Conditions. 45(December 2017), 162–170. https://doi.org/10.1111/jcpe.12946 - Perry, V. H. (2004). The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease. Brain, behavior, and immunity, 18(5), 407–413. https://doi.org/10.1016/j.bbi.2004.01.004 - Rosania, A. E., Low, K. G., McCormick, C. M., & Rosania, D. A. (2009). Stress, depression, 44 cortisol, and periodontal disease. Journal of periodontology, 80(2), 260–266. https://doi.org/10.1902/jop.2009.080334 - Saletu, A., Pirker- Fruhauf, H., Saletu, F., Linzmayer, L., Anderer, P., & Matejka, M. (2005). Controlled clinical and psychometric studies on the relation between periodontitis and depressive mood. Journal of Clinical Periodontology, 32, 1219–1225. https://doi.org/10.1111/j.1600-051X.2005.00855.x - Sanz, M., Beighton, D., Curtis, M. A., Cury, J. A., Dige, I., Dommisch, H., Ellwood, R., Rodrigo, A., Herrera, D., & Mark, C. (2017). Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases . Consensus report of group 1 of the Joint EFP / ORCA workshop on the boundaries between caries and periodontal disease. 44. https://doi.org/10.1111/jcpe.12682 - Sanz, M., Ceriello, A., Buysschaert, M., Chapple, I., Demmer, R. T., Graziani, F., Herrera, D., Jepsen, S., & Lione, L. (2019). Scientific evidence on the links between periodontal diseases and diabetes : Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. January, 138–149. https://doi.org/10.1111/jcpe.12808 - Sanz, M., Kornman, K., & working group 3 of the joint EFP/AAP workshop (2013). Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. Journal of periodontology, 84(4 Suppl), S164–S169. https://doi.org/10.1902/jop.2013.1340016 - Solis, A. C. de O., Marques, A. H., Dominguez, W. V., Prado, E. B. de A., Pannuti, C. M., Lotufo, R. F. M., & Lotufo-Neto, F. (2016). Evaluation of periodontitis in hospital outpatients with major depressive disorder. A focus on gingival and circulating cytokines. Brain, Behavior, and Immunity, 53, 49–53. https://doi.org/10.1016/j.bbi.2015.11.014 - Valkanova, V., Ebmeier, K. P., & Allan, C. L. (2013). CRP , IL-6 and depression : A systematic review and meta-analysis of longitudinal studies. Journal of Affective Disorders, 150(3), 736–744. https://doi.org/10.1016/j.jad.2013.06.004 - Verma, D., Kumar, P., Ashok, G., & Dubey, K. (2018). Insights into the human oral microbiome. Archives of Microbiology, 0(0), 0. https://doi.org/10.1007/s00203-018-1505-3 45 - Vignoletti, F., & Abrahamsson, I. (2012). Quality of reporting of experimental research in implant dentistry. Critical aspects in design, outcome assessment and model validation. Journal of clinical periodontology, 39 Suppl 12, 6–27. https://doi.org/10.1111/j.1600-051X.2011.01830.x - Virto, L., Cano, P., Jiménez-Ortega, V., Fernández-Mateos, P., González, J., Esquifino, A. I., & Sanz, M. (2018). Obesity and periodontitis: An experimental study to evaluate periodontal and systemic effects of comorbidity. Journal of periodontology, 89(2), 176–185. https://doi.org/10.1902/jop.2017.170355 - Warren, K. R., Postolache, T. T., Groer, M. E., Pinjari, O., Kelly, D. L., & Reynolds, M. A. (2014). Role of chronic stress and depression in periodontal diseases. Periodontology 2000, 64(1), 127–138. https://doi.org/10.1111/prd.12036 - Wiborg, O. (2013). Chronic mild stress for modeling anhedonia. Cell and tissue research, 354(1), 155–169. https://doi.org/10.1007/s00441-013-1664-0 - Willner, P. (2005). Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology, 52(2), 90–110. https://doi.org/10.1159/000087097 - Young, J. J., Bruno, D., & Pomara, N. (2014). A review of the relationship between proin fl ammatory cytokines and major depressive disorder. Journal of Affective Disorders, 169, 15–20. https://doi.org/10.1016/j.jad.2014.07.032 - Zenobia, C., & Hajishengallis, G. (2015). Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis. Virulence, 6(3), 236–243. https://doi.org/10.1080/21505594.2014.999567 - Zheng, D. X., Kang, X. N., Wang, Y. X., Huang, Y. N., Pang, C. F., Chen, Y. X., Kuang, Z. L., & Peng, Y. (2021). Periodontal disease and emotional disorders: A meta-analysis. Journal of Clinical Periodontology, 48(2), 180–204. https://doi.org/10.1111/jcpe.1339 NO Trabajo de Fin de Máster en Ciencias Odontológicas, Facultad de Odontología UCM, Departamento de Especialidades Clínicas Odontológicas, Curso 2020/2021 DS Docta Complutense RD 8 jul 2024