RT Journal Article
T1 Multi-disease validation of the RUDAS for cognitive screening in Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis
A1 Delgado Álvarez, Alfonso
A1 Díez Cirarda, María
A1 Delgado Alonso, Cristina
A1 Hernández Lorenzo, Laura
A1 Cuevas, Constanza
A1 Valles Salgado, María
A1 Montero Escribano, Paloma
A1 Gil Moreno, María José
A1 Matías-Guiu Guía, Jorge
A1 García-Ramos García, María Del Rocío
A1 Matias-Guiu, Jordi A.
AB Background: The Rowland Universal Dementia Assessment Scale (RUDAS) is a cognitive test with favorable diagnostic properties for detecting dementia and a low influence of education and cultural biases. Objective: We aimed to validate the RUDAS in people with Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Methods: We enrolled one hundred and fifty participants (60 with AD, 30 with PD, 60 with MS, and 120 healthy controls (HC)). All clinical groups completed a comprehensive neuropsychological battery, RUDAS, and standard cognitive tests of each disorder: MMSE, SCOPA-COG, and Symbol Digit Modalities Test. Intergroup comparisons between clinical groups and HC and ROC curves were estimated. Random Forest algorithms were trained and validated to detect cognitive impairment using RUDAS and rank the most relevant scores. Results: The RUDAS scores were lower in patients with AD, and patients with PD and MS showed cognitive impairment compared to healthy controls. Effect sizes were generally large. The total score was the most discriminative, followed by the memory score. Correlations with standardized neuropsychological tests were moderate to high. Random Forest algorithms obtained accuracies over 80–90% using the RUDAS for diagnosing AD and cognitive impairment associated with PD and MS. Conclusion: Our results suggest the RUDAS is a valid test candidate for multi-disease cognitive screening tool in AD, PD, and MS.
PB IOS Press
SN 1387-2877
SN 1875-8908
YR 2023
FD 2023-01-17
LK https://hdl.handle.net/20.500.14352/104011
UL https://hdl.handle.net/20.500.14352/104011
LA eng
NO Delgado-Álvarez A, Díez-Cirarda M, Delgado-Alonso C, Hernández-Lorenzo L, Cuevas C, Valles-Salgado M, et al. Multi-Disease Validation of the RUDAS for Cognitive Screening in Alzheimer’s Disease, Parkinson’s Disease, and Multiple Sclerosis. JAD 2023;91:705–17. https://doi.org/10.3233/JAD-220907.
NO Instituto de Salud Carlos III
NO Comisión Europea
DS Docta Complutense
RD 23 abr 2025