RT Journal Article
T1 Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations
A1 Navas-Olive, Andrea
A1 Valero, Manuel
A1 Jurado-Parras, Teresa
A1 Salas-Quiroga, Adán de
A1 Averkin, Robert G.
A1 Gambino, Giuditta
A1 Cid, Elena
A1 Liset, M. de la Prida
AB Theta oscillations play a major role in temporarily defining the hippocampal rate code by translating behavioral sequences into neuronal representations. However, mechanisms constraining phase timing and cell-type-specific phase preference are unknown. Here, we employ computational models tuned with evolutionary algorithms to evaluate phase preference of individual CA1 pyramidal cells recorded in mice and rats not engaged in any particular memory task. We applied unbiased and hypothesis-free approaches to identify effects of intrinsic and synaptic factors, as well as cell morphology, in determining phase preference. We found that perisomatic inhibition delivered by complementary populations of basket cells interacts with input pathways to shape phase-locked specificity of deep and superficial pyramidal cells. Somatodendritic integration of fluctuating glutamatergic inputs defined cycle-by-cycle by unsupervised methods demonstrated that firing selection is tuneable across sublayers. Our data identify different mechanisms of phase-locking selectivity that are instrumental for flexible dynamical representations of theta sequences.
PB Nature Research
SN ESSN 2041-1723
YR 2020
FD 2020-05-05
LK https://hdl.handle.net/20.500.14352/6545
UL https://hdl.handle.net/20.500.14352/6545
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Hungarian National Office for Research and Technology
NO Ministerio de Educación y Formación Profesional
DS Docta Complutense
RD 3 abr 2025