RT Journal Article
T1 Plant protein peptidase inhibitors: an evolutionary overview based on comparative genomics
A1 Santamaría, María Estrella
A1 Díaz Mendoza, María Mercedes
A1 Diaz, Isabel
A1 Martinez, Manuel
AB Background: Peptidases are key proteins involved in essential plant physiological processes. Although protein peptidase inhibitors are essential molecules that modulate peptidase activity, their global presence in different plant species remains still unknown. Comparative genomic analyses are powerful tools to get advanced knowledge into the presence and evolution of both, peptidases and their inhibitors across the Viridiplantae kingdom. Results: A genomic comparative analysis of peptidase inhibitors and several groups of peptidases in representative species of different plant taxonomic groups has been performed. The results point out: i) clade-specific presence is common to many families of peptidase inhibitors, being some families present in most land plants; ii) variability is a widespread feature for peptidase inhibitory families, with abundant species-specific (or clade-specific) gene family proliferations; iii) peptidases are more conserved in different plant clades, being C1A papain and S8 subtilisin families present in all species analyzed; and iv) a moderate correlation among peptidases and their inhibitors suggests that inhibitors proliferated to control both endogenous and exogenous peptidases.Conclusions: Comparative genomics has provided valuable insights on plant peptidase inhibitor families and could explain the evolutionary reasons that lead to the current variable repertoire of peptidase inhibitors in specific plant clades.
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/93023
UL https://hdl.handle.net/20.500.14352/93023
LA eng
NO Santamaría, M.E., Diaz-Mendoza, M., Diaz, I. et al. Plant protein peptidase inhibitors: an evolutionary overview based on comparative genomics. BMC Genomics 15, 812 (2014). https://doi.org/10.1186/1471-2164-15-812
NO Ministerio de Educación y Ciencia (España)
NO Ministerio de Economía y Competitividad (España)
NO European Commission
DS Docta Complutense
RD 12 abr 2025