RT Journal Article
T1 Very early brain damage leads to remodeling of the working memory system in adulthood: A combined fMRI/ Tractography study
A1 Froudist Walsh, Sean
A1 Karolis, Vyacheslav
A1 Caldinelli, Chiara
A1 Brittain, Philip J.
A1 Kroll, Jasmin
A1 Rodríguez Toscano, Elisa
A1 Tesse, Marcelo
A1 Colquhoun, Matthew
A1 Howes, Oliver
A1 Dell' Acqua, Flavio
A1 Thiebaut de Schotten, Michel
A1 Murray, Robin M.
A1 Williams, Steven C.R.
A1 Nosarti, Chiara
AB The human brain can adapt to overcome injury even years after an initial insult. One hypothesis states that early brain injury survivors,by taking advantage of critical periods of high plasticity during childhood, should recover more successfully than those who suffer injurylater in life. This hypothesis has been challenged by recent studies showing worse cognitive outcome in individuals with early brain injury,compared with individuals with later brain injury, with working memory particularly affected. We invited individuals who sufferedperinatal brain injury (PBI) for an fMRI/diffusion MRI tractography study of working memory and hypothesized that, 30 years after theinitial injury, working memory deficits in the PBI group would remain, despite compensatory activation in areas outside the typicalworking memory network. Furthermore we hypothesized that the amount of functional reorganization would be related to the level ofinjury to the dorsal cingulum tract, which connects medial frontal and parietal working memory structures. We found that adults whosuffered PBI did not significantly differ from controls in working memory performance. They exhibited less activation in classic frontoparietalworking memory areas and a relative overactivation of bilateral perisylvian cortex compared with controls. Structurally, thedorsal cingulum volume and hindrance-modulated orientational anisotropy was significantly reduced in the PBI group. Furthermorethere was uniquely in the PBI group a significant negative correlation between the volume of this tract and activation in the bilateralperisylvian cortex and a positive correlation between this activation and task performance. This provides the first evidence of compensatoryplasticity of the working memory network following PBI.
PB Society for Neuroscience
SN 1529-2401
SN 0270-6474
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/113014
UL https://hdl.handle.net/20.500.14352/113014
LA eng
NO Froudist Walsh S., Karolis V., Caldinelli C., Brittain P.J., Kroll J., Rodríguez Toscano E., Tesse M., Colquhoun M., Howes O., Dell'Acqua F., Thiebaut de Schotten M., Murray R.M., Williams S.C. & Nosarti C.(2015). Very Early Brain Damage Leads to Remodeling of the Working Memory System in Adulthood: A Combined fMRI/Tractography Study. The Journal of Neuroscience, 35(48):15787-15799  99.
DS Docta Complutense
RD 15 dic 2025