RT Journal Article
T1 Effects of neonatal programming on hypothalamic mechanisms controlling energy balance
A1 Contreras Jiménez, Cristina
A1 Garrido Novelle, Marta
A1 Leis, Rosaura
A1 Diéguez, Carlos
A1 Skrede, Silje
A1 López, Miguel
AB The prevalence of overweight and obesity in most developed countries has markedly increased during the last decades. In addition to genetic, hormonal, and metabolic influences, environmental factors like fetal and neonatal nutrition play key roles in the development of obesity. Interestingly, overweight during critical developmental periods of fetal and/or neonatal life has been demonstrated to increase the risk of obesity throughout juvenile life into adulthood. In spite of this evidence, the specific mechanisms underlying this fetal/neonatal programming are not perfectly understood. However, it is clear that circulating hormones such as insulin and leptin play a critical role in the development and programming of hypothalamic circuits regulating energy balance. Here, we review what is currently known about the impact of perinatal malnutrition on the mechanisms regulating body weight homeostasis. Understanding these molecular mechanisms may provide new targets for the treatment of obesity.
PB Thieme Gruppe
SN 0018-5043
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/94900
UL https://hdl.handle.net/20.500.14352/94900
LA eng
NO Contreras, C., et al. «Effects of Neonatal Programming on Hypothalamic Mechanisms Controlling Energy Balance». Hormone and Metabolic Research, vol. 45, n.o 13, agosto de 2013, pp. 935-44. https://doi.org/10.1055/s-0033-1351281.
DS Docta Complutense
RD 11 abr 2025