RT Journal Article
T1 Plasma antioxidant capacity is reduced in Asperger syndrome
A1 Parellada Redondo, María José
A1 Moreno Ruiz, María del Carmen
A1 Mac-Dowell, Karina
A1 Leza, Juan Carlos
A1 Giraldez, Marisa
A1 Bailón, Concepción
A1 Castro, Carmen
A1 Miranda-Azpiazu, Patricia
A1 Fraguas Herráez, David
A1 Arango López, Celso
AB Recent evidence suggests that children with autism have impaired detoxification capacity and may suffer from chronic oxidative stress. To our knowledge, there has been no study focusing on oxidative metabolism specifically in Asperger syndrome (a milder form of autism) or comparing this metabolism with other psychiatric disorders. In this study, total antioxidant status (TAOS), non-enzymatic (glutathione and homocysteine) and enzymatic (catalase, superoxide dismutase, and glutathione peroxidase) antioxidants, and lipid peroxidation were measured in plasma or erythrocyte lysates in a group of adolescent patients with Asperger syndrome, a group of adolescents with a first episode of psychosis, and a group of healthy controls at baseline and at 8-12 weeks. TAOS was also analyzed at 1 year. TAOS was reduced in Asperger individuals compared with healthy controls and psychosis patients, after covarying by age and antipsychotic treatment. This reduced antioxidant capacity did not depend on any of the individual antioxidant variables measured. Psychosis patients had increased homocysteine levels in plasma and decreased copper and ceruloplasmin at baseline. In conclusion, Asperger patients seem to have chronic low detoxifying capacity. No impaired detoxifying capacity was found in the first-episode psychosis group in the first year of illness.
PB Elsevier
SN 0022-3956
YR 2012
FD 2012-03-13
LK https://hdl.handle.net/20.500.14352/115190
UL https://hdl.handle.net/20.500.14352/115190
LA eng
NO Parellada M, Moreno C, Mac-Dowell K, Leza JC, Giraldez M, Bailón C, Castro C, Miranda-Azpiazu P, Fraguas D, Arango C. Plasma antioxidant capacity is reduced in Asperger syndrome. J Psychiatr Res. 2012 Mar;46(3):394-401. doi: 10.1016/j.jpsychires.2011.10.004
DS Docta Complutense
RD 7 abr 2025