RT Journal Article
T1 A glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic and logic gate for smart delivery
A1 Mayol Hornero, Beatriz
A1 Díez-Sánchez, Paula
A1 Sánchez Sánchez, Alfredo
A1 Torre, Cristina de la
A1 Villalonga, Anabel
A1 Lucena-Sánchez, Elena
A1 Sancenón, Félix
A1 Martínez Ruiz, María Paloma
A1 Vilela García, Diana
A1 Martínez-Máñez, Ramón
A1 Villalonga Santana, Reynaldo
AB This work describes the assembly of a novel enzyme-controlled nanomachine operated through an AND Boolean logic gate for on-command delivery. The nanodevice was constructed on Au-mesoporous silica Janus nanoparticles capped with a thiol-sensitive gate-like molecular ensemble on the mesoporous face and functionalized with glutathione reductase on the gold face. This autonomous nanomachine employed NADPH and glutathione disulfide as input chemical signals, leading to the enzymatic  production of reduced glutathione that causes the disruption of the gating mechanism on the mesoporous face and the consequent payload release as an output signal. The nanodevice was successfully used for the autonomous release of doxorubicin in HeLa cancer cells and RAW 264.7 macrophage cells.
PB The Royal Society of Chemistry
SN 2040-3364
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/93302
UL https://hdl.handle.net/20.500.14352/93302
LA eng
NO Mayol, B., Diez, P., Sánchez, A., Paredes, C. D. L. T., Villalonga, A., Lucena-Sánchez, E.,   Sancenón, F., Martínez-Ruiz, P., Vilela, D., Martinez-Manez, R., Villalonga, R.* (2021). Glutathione disulfide-sensitive Janus nanomachine controlled by an enzymatic AND logic gate for smart delivery. Nanoscale 13: 18616-18625.
NO Ministerio de Economía y Competitividad (España)
NO Generalitat Valenciana
DS Docta Complutense
RD 8 abr 2025