RT Journal Article
T1 Target volume‐guarantee in high‐frequency oscillatory ventilation for preterm respiratory distress syndrome: Low volumes and high frequencies lead to adequate ventilation
A1 Solís García, Gonzalo
A1 González Pacheco, Noelia
A1 Ramos Navarro, Cristina
A1 Rodríguez Sánchez de la Blanca, Ana
A1 Sánchez Luna, Manuel Ramón
AB Background and objectives: Respiratory distress syndrome (RDS) and ventilation-induced lung injury lead to significant morbidity in preterm infants. High-frequency oscillatory ventilation with volume-guarantee (HFOV-VG) has been used as a rescue therapy and might lead to lower rates of death and bronchopulmonary dysplasia, especially when using low tidal volumes and high frequencies. The aim of the study was to define HFOV-VG parameters leading to adequate ventilation in the first 72 h of preterm RDS using a low volume and high-frequency strategy.Design and methods: Retrospective cohort study in a tertiary-level neonatology unit. Infants <32 weeks with severe respiratory insufficiency needing HFOV-VG were included. Patients were ventilated following a standard mechanical ventilation aiming for low tidal volumes and high frequencies. Clinical data, perinatal characteristics and high-frequency parameters corresponding with adequate ventilation were recorded.Results: 116 patients were included. Median gestational age was 25 weeks (interquartile range [IQR] = 24-27), median birth weight 724 g (IQR = 600-900 g). HFOV-VG was started at 2 h, median high-frequency tidal volume was 1.63 ml/kg (IQR = 1.44-1.84) and median frequency was 16 Hz (IQR = 15-18). Weight-adjusted tidal volumes did not depend on gestational age, antenatal corticosteroids nor chorioamnionitis, and were inversely correlated with frequencies (R 2 = -0.10, p = .001).Conclusion: HFOV-VG can reach adequate ventilation at high frequencies when using adequate volumes, providing a feasible ventilation strategy that might be of help in preterm infants with RDS.
PB Wiley
SN 8755-6863
SN 1099-0496
YR 2021
FD 2021-06-09
LK https://hdl.handle.net/20.500.14352/99373
UL https://hdl.handle.net/20.500.14352/99373
LA eng
NO Solís-García G, González-Pacheco N, Ramos-Navarro C, Rodríguez Sánchez de la Blanca A, Sánchez-Luna M. Target volume-guarantee in high-frequency oscillatory ventilation for preterm respiratory distress syndrome: Low volumes and high frequencies lead to adequate ventilation. Pediatr Pulmonol. 2021 Aug;56(8):2597-2603. doi: 10.1002/ppul.25529. Epub 2021 Jun 9. PMID: 34107176.
DS Docta Complutense
RD 9 abr 2025