RT Journal Article
T1 Faecal Short-Chain, Long-Chain, and Branched-Chain Fatty Acids as Markers of Different Chronic Inflammatory Enteropathies in Dogs
A1 Higueras, Cristina
A1 Sainz Rodríguez, Ángel
A1 García-Sancho Téllez, Mercedes Guadalupe
A1 Rodríguez Franco, Fernando
A1 Rey Muñoz, Ana Isabel
AB Chronic inflammatory enteropathies (CIEs) are classified based on treatment trials, and new methods are being sought for earlier differentiation and characterization. Giardia infection (GIA) is one of the first differential diagnoses and may be present in CIE-affected dogs. The aim of this study was to evaluate the faecal characteristics and faecal fatty acid profile (short, medium, long, and branched-chain fatty acids) in dogs with food-responsive enteropathy (FRE), immunosuppressant-responsive enteropathy (IRE), and dogs infected with Giardia compared to healthy control (HC) animals as a potential non-invasive indicator of intestinal health that helps in the differentiation of CIEs. The C16:1n-7 percentage (p = 0.0001) and C16:1n-7/C16:0 ratio (p = 0.0001) served to differentiate between HC, FRE, and IRE. IRE dogs presented lower levels of short-chain fatty acids (∑SCFAs) (p = 0.0008) and acetic acid (C2) (p = 0.0007) compared to the other three groups and lower propionic acid (C3) (p = 0.0022) compared to HCs. IRE and GIA presented higher faecal fat content (p = 0.0080) and ratio of iso/anteiso branched-chain fatty acids (BCFAs) compared to HC and FRE. Correlations between some fatty acids and desaturation indices with the canine inflammatory bowel disease activity index and faecal characteristics were observed, suggesting that these compounds could play an important role in the pathogenesis of these diseases.
PB MDPI
SN 2076-2615
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/108768
UL https://hdl.handle.net/20.500.14352/108768
LA eng
NO Higueras, C.; Sainz, Á.;  García-Sancho, M.;  Rodríguez-Franco, F.; Rey, A.I.  Faecal Short-Chain, Long-Chain,  and Branched-Chain Fatty Acids  as Markers of Different Chronic  Inflammatory Enteropathies in  Dogs. Animals 2024, 14, 1825.  https://doi.org/10.3390/ani14121825
NO C.H. recibió una beca para el desarrollo de doctoradode Becas Santander de la Universidad Complutense de Madrid (CT15/23).
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 9 abr 2025