RT Journal Article
T1 Autophagy in hepatic adaptation to stress
A1 Hazari, Younis
A1 Bravo San Pedro, José Manuel
A1 Hetz, Claudio
A1 Galluzzi, Lorenzo
A1 Kroemer, Guido
AB Autophagy is an evolutionarily ancient process whereby eukaryotic cells eliminate disposable or potentially dangerous cytoplasmic material, to support bioenergetic metabolism and adapt to stress. Accumulating evidence indicates that autophagy operates as a critical quality control mechanism for the maintenance of hepatic homeostasis in both parenchymal (hepatocytes) and non-parenchymal (stellate cells, sinusoidal endothelial cells, Kupffer cells) compartments. In line with this notion, insufficient autophagy has been aetiologically involved in the pathogenesis of multiple liver disorders, including alpha-1-antitrypsin deficiency, Wilson disease, non-alcoholic steatohepatitis, liver fibrosis and hepatocellular carcinoma. Here, we critically discuss the importance of functional autophagy for hepatic physiology, as well as the mechanisms whereby defects in autophagy cause liver disease.
PB Elsevier
SN 0168-8278
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/128935
UL https://hdl.handle.net/20.500.14352/128935
LA eng
NO Hazari Y, Bravo-San Pedro JM, Hetz C, Galluzzi L, Kroemer G. Autophagy in hepatic adaptation to stress. Journal of hepatology. 2020;72(1):183–196.
DS Docta Complutense
RD 22 may 2026