RT Journal Article
T1 The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway.
A1 Román, Elvira
A1 Correia, C. Inês Ribeiro
A1 Prieto, Daniel
A1 Alonso Monge, Rebeca
A1 Pla Alonso, Jesús
AB In 1993, Brewster and Gustin described the existence of a kinase whose activity was essential for Saccharomyces cerevisiae to grow in environments with high osmolarity. This led to the discovery of the HOG pathway, a MAP kinase (MAPK) pathway that has been revealed to be crucial to respond to a wide range of stress conditions frequently encountered by fungi in their common habitats. MAPK signaling is initiated at the plasma membrane, where triggering stimuli lead to a phosphorylation cascade that ultimately activates transcription factors to ensure an appropriate adaptive response. In pathogenic fungi, the HOG pathway gains special significance as it is involved in traits related to pathogenicity; these include biofilm formation, adhesion to surfaces, and morphogenetic and epigenetic transitions. It also plays a role in controlling both the pathogen and the commensal state program. Understanding the signals leading to its activation, the elements of the pathways and the targets of the pathway are therefore of primary importance in the design of novel antifungals.
PB Springer Verlag
SN 1618-1905
YR 2019
FD 2019-03-14
LK https://hdl.handle.net/20.500.14352/13367
UL https://hdl.handle.net/20.500.14352/13367
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
DS Docta Complutense
RD 3 may 2024