RT Journal Article
T1 Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice
A1 Maldonado Bautista, Estela
A1 López-Gordillo, Yamila
A1 Partearroyo, Teresa
A1 Varela Moreiras, Gregorio
A1 Martínez Álvarez, Concepción
A1 Pérez Miguelsanz, Juliana
AB It is widely accepted that maternal folic acid (FA) deficiency during pregnancy is a risk factor for abnormal development. The tongue, with multiple genes working together in a coordinated cascade in time and place, has emerged as a target organ for testing the effect of FA during development. A FA-deficient (FAD) diet was administered to eight-week-old C57/BL/6J mouse females for 2–16 weeks. Pregnant dams were sacrificed at gestational day 17 (E17). The tongues and heads of 15 control and 210 experimental fetuses were studied. In the tongues, the maximum width, base width, height and area were compared with width, height and area of the head. All measurements decreased from 10% to 38% with increasing number of weeks on maternal FAD diet. Decreased head and tongue areas showed a harmonic reduction (Spearman nonparametric correlation, Rho = 0.802) with respect to weeks on a maternal FAD diet. Tongue congenital abnormalities showed a 10.9% prevalence, divided in aglossia (3.3%) and microglossia (7.6%), always accompanied by agnathia (5.6%) or micrognathia (5.2%). This is the first time that tongue alterations have been related experimentally to maternal FAD diet in mice. We propose that the tongue should be included in the list of FA-sensitive birth defect organs due to its relevance in several key food and nutrition processes.
PB MDPI
SN 2072-6643
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/19103
UL https://hdl.handle.net/20.500.14352/19103
LA eng
NO Ministerio de Sanidad
NO Instituto de Salud Carlos III/Ministerio de Ciencia e Innovación (MICCIN)
NO Universidad Complutense de Madrid/Banco de Santander
DS Docta Complutense
RD 20 ago 2024