RT Journal Article
T1 Antimicrobial sensitisers: Gatekeepers to avoid the development of multidrug-resistant bacteria
A1 Wang, Hanfei
A1 Yang, Yingying
A1 Wang, Simeng
A1 Badawy, Sara
A1 Wang, Xu
A1 Ares Lombán, Irma
A1 Martínez Caballero, Marta
A1 López Torres, Bernardo
A1 Martínez Larrañaga, María Rosa
A1 Anadón Navarro, Arturo Ramón
A1 Martínez Caballero, María Aranzazu
A2 De Smedt, Stefaan
AB The resistance of multidrug-resistant bacteria to existing antibiotics forces the continued development of new antibiotics and antibacterial agents, but the high costs and long timeframe involved in the development of new agents renders the hope that existing antibiotics may again play a part. The “antibiotic adjuvant” is an indirect antibacterial strategy, but its vague concept has, in the past, limited the development speed of related drugs. In this review article, we put forward an accurate concept of a “non-self-antimicrobial sensitisers (NSAS)”, to distinguish it from an “antibiotic adjuvant”, and then discuss several scientific methods to restore bacterial sensitivity to antibiotics, and the sources and action mechanism of existing NSAS, in order to guide the development and further research of NSAS.
PB Elsevier
SN 0168-3659
YR 2024
FD 2024-03-16
LK https://hdl.handle.net/20.500.14352/102719
UL https://hdl.handle.net/20.500.14352/102719
LA eng
NO Authors contribution: Hanfei Wang: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Yingying Yang: Writing – original draft, Visualization, Supervision, Investigation, Formal analysis, Conceptualization. Simeng Wang: Writing – original draft, Methodology, Investigation, Formal analysis, Conceptualization. Sara Badawy: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Irma Ares: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Marta Martínez: Writing – original draft, Visualization, Methodology, Investigation, Formal analysis, Conceptualization. Bernardo Lopez-Torres: Writing – original draft, Visualization, Supervision, Methodology, Investigation, Formal analysis, Conceptualization. María-Rosa Martínez-Larranaga: ˜ Writing – original draft, Visualization, Supervision, Methodology, Investigation, Formal analysis, Conceptualization. Xu Wang: Writing – review & editing, Writing – original draft, Visualization, Supervision, Project administration, Methodology, Investigation, Formal analysis, Conceptualization. Arturo Anadon: ´ Writing – review & editing, Writing – original draft, Supervision, Project administration, Investigation, Conceptualization. María-Aranzazu ´ Martínez: Writing – review & editing, Writing – original draft, Validation, Supervision, Projectadministration, Methodology, Investigation, Formal analysis, Conceptualization.
NO Major Special Science and Technology Plan (202302AA310020)
NO National Natural Science Foundation of China (NSFC) (32072925)
NO Project Ref. PID2020-115979RR-C33 from Ministerio de Ciencia e Innovación, Spain (Project/AEI/10.13039/501100011033)
DS Docta Complutense
RD 6 oct 2024