RT Journal Article
T1 Mesothelial-to-Mesenchymal Transition and Exosomes in Peritoneal Metastasis of Ovarian Cancer
A1 Pascual Antón, Lucía
A1 Cardeñes, Beatriz
A1 Sainz de la Cuesta, Ricardo
A1 González Cortijo, Lucía
A1 López Cabrera, Manuel
A1 Cabañas, Carlos
A1 Sandoval, Pilar
AB Most patients with ovarian cancer (OvCA) present peritoneal disseminated disease at the time of diagnosis. During peritoneal metastasis, cancer cells detach from the primary tumor and disseminate through the intraperitoneal fluid. The peritoneal mesothelial cell (PMC) monolayer that lines the abdominal cavity is the first barrier encountered by OvCA cells. Subsequent progression of tumors through the peritoneum leads to the accumulation into the peritoneal stroma of a sizeable population of carcinoma-associated fibroblasts (CAFs), which is mainly originated from a mesothelial-to-mesenchymal transition (MMT) process. A common characteristic of OvCA patients is the intraperitoneal accumulation of ascitic fluid, which is composed of cytokines, chemokines, growth factors, miRNAs, and proteins contained in exosomes, as well as tumor and mesothelial suspended cells, among other components that vary in proportion between patients. Exosomes are small extracellular vesicles that have been shown to mediate peritoneal metastasis by educating a pre-metastatic niche, promoting the accumulation of CAFs via MMT, and inducing tumor growth and chemoresistance. This review summarizes and discusses the pivotal role of exosomes and MMT as mediators of OvCA peritoneal colonization and as emerging diagnostic and therapeutic targets.
PB MPDI
SN 1422-0067
YR 2021
FD 2021-10-25
LK https://hdl.handle.net/20.500.14352/4836
UL https://hdl.handle.net/20.500.14352/4836
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Consejo Superior de Investigaciones Científicas (CSIC)
DS Docta Complutense
RD 6 abr 2025