RT Journal Article
T1 Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer
A1 Otero Sobrino, Álvaro
A1 Blanco Carlón, Pablo
A1 Navarro Aguadero, Miguel Ángel
A1 Gallardo, Miguel
A1 Martínez López, Joaquín
A1 Velasco Estévez, María
AB Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical extracellular and intracellular changes, translating them into cation influx to adapt and respond to these physical cues. All cells in the organism are mechanosensitive, and these physical cues have proven to have an important role in regulating proliferation, cell fate and differentiation, migration and cellular stress, among other processes. Indeed, the mechanical properties of the extracellular matrix in cancer change drastically due to high cell proliferation and modification of extracellular protein secretion, suggesting an important contribution to tumor cell regulation. In this review, we describe the physiological significance of mechanosensitive ion channels, emphasizing their role in cancer and immunity, and providing compelling proof of the importance of continuing to explore their potential as new therapeutic targets in cancer research.
PB MDPI
SN 1422-0067
YR 2023
FD 2023-09-05
LK https://hdl.handle.net/20.500.14352/106015
UL https://hdl.handle.net/20.500.14352/106015
LA eng
NO Otero-Sobrino, Á.; Blanco-Carlón, P.; Navarro-Aguadero, M.Á.; Gallardo, M.; Martínez-López, J.; Velasco-Estévez, M. Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer. Int. J. Mol. Sci. 2023, 24, 13710. https://doi.org/10.3390/ijms241813710
DS Docta Complutense
RD 10 abr 2025