RT Journal Article
T1 Searching for Primary Predictors of Conversion from Mild Cognitive Impairment to Alzheimer’s Disease: A Multivariate Follow-Up Study
A1 López García, María Eugenia
A1 Turrero Nogués, Agustín
A1 Cuesta Prieto, Pablo
A1 López Sanz, David
A1 Bruña Fernández, Ricardo
A1 Marcos Dolado, Alberto
A1 Gil Gregorio, Pedro
A1 Yus, Miguel
A1 Barabash Bustelo, Ana
A1 Cabranes Díaz, José Antonio
A1 Maestu Unturbe, Fernando
A1 Fernández Lucas, Alberto Amable
AB Recent proposals of diagnostic criteria within the healthy aging-Alzheimer’s disease (AD) continuum stressed the role of biomarker information. More importantly, such information might be critical to predict those mild cognitive impairment (MCI) patients at a higher risk of conversion to AD. Usually, follow-up studies utilize a reduced number of potential markers although the conversion phenomenon may be deemed as multifactorial in essence. In addition, not only biological but also cognitive markers may play an important role. Considering this background, we investigated the role of cognitive reserve, cognitive performance in neuropsychological testing, hippocampal volumes, APOE genotype, and magnetoencephalography power sources to predict the conversion to AD in a sample of 33 MCI patients. MCIs were followed up during a 2-year period and divided into two subgroups according to their outcome: The “stable” MCI group (sMCI, 21 subjects) and the “progressive” MCI group (pMCI, 12 subjects). Baseline multifactorial information was submitted to a hierarchical logistic regression analysis to build a predictive model of conversion to AD. Results indicated that the combination of left hippocampal volume, occipital cortex theta power, and clock drawing copy subtest scores predicted conversion to AD with a 100% of sensitivity and 94.7% of specificity. According to these results it might be suggested that anatomical, cognitive, and neurophysiological markers may be considered as “first order” predictors of progression to AD, while APOE or cognitive reserve proxies might play a more secondary role.
PB IOS Press
SN 1387-2877
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/100161
UL https://hdl.handle.net/20.500.14352/100161
LA eng
NO López ME, Turrero A, Cuesta P, López-Sanz D, Bruña R, Marcos A, Gil P, Yus M, Barabash A, Cabranes JA, Maestú F, Fernández A. Searching for Primary Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease: A Multivariate Follow-Up Study. J Alzheimers Dis. 2016 Mar 5;52(1):133-43. doi: 10.3233/JAD-151034
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 7 jun 2025