RT Journal Article
T1 Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses
A1 Pérez-Carrasco, María J
A1 Carballo-Álvarez, Jesús
A1 Barbur, John L
A1 Puell, Maria C
AB Purpose: Early detection of structural changes in retinal ganglion cells (RGCs) and corresponding changes in visual function is important in early degenerative diseases of theretina, but the sensitivity of both measurements is limited by the inherent variability in healthy subjects. This study investigates the relationships between RGC-relatedlayer thicknesses and foveal and parafoveal flicker modulation sensitivity (FMS) across photopic and mesopic light levels in healthy subjects.Methods: Photopic and mesopic FMS was measured in 56 young adults, at the point of fixation and at an eccentricity of 5 degrees, in each of the four quadrants. Spectraldomainoptical coherence tomography (SD-OCT) was used to measure retinal thicknesses. Relationships between foveal and parafoveal FMS and the retinal thickness in the corresponding region were examined after adjusting for confounding variables.Results: Total macular and inner retinal layer (IRL) thicknesses in the parafoveal ring were significant predictors of photopic (P = 0.034) and mesopic (P = 0.034) parafovealFMS, respectively. The superior peripapillary retinal nerve fiber layer (pRNFL) thickness was a contributing factor to the inferior parafoveal FMS (photopic: P = 0.006 andmesopic: P = 0.021) and the inferior pRNFL thickness was also a contributing factor to the superior parafoveal FMS (photopic: P < 0.001 and mesopic: P = 0.015).Conclusions: The pRNFL thicknesses predict parafoveal FMS for both mesopic and photopic conditions in healthy eyes.Translational Relevance: Themeasurement of rapid flicker sensitivity in the parafoveal retina together with the pRNFL thickness profiles measured before the onset of disease,may provide a more sensitive biomarker for detecting loss of sensitivity caused by the earliest neurodegenerative changes in the eyes.
PB ARVO JOURNALS
YR 2021
FD 2021-10-14
LK https://hdl.handle.net/20.500.14352/113295
UL https://hdl.handle.net/20.500.14352/113295
LA eng
NO Pérez-Carrasco MJ, Carballo-Álvarez J, Barbur JL, Puell MC. Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses. Transl Vis Sci Technol. 2021 Oct 4;10(12):16. doi: 10.1167/tvst.10.12.16. PMID: 34647964; PMCID: PMC8525864.
DS Docta Complutense
RD 9 abr 2025