RT Journal Article
T1 Osteoimmune Properties of Mesoporous Bioactive Nanospheres: A Study on T Helper Lymphocytes
A1 Casarrubios Molina, Laura
A1 Cicuéndez Maroto, Mónica
A1 Vallet Regí, María Dulce Nombre
A1 Portolés Pérez, María Teresa
A1 Arcos Navarrete, Daniel
A1 Feito Castellano, María José
AB Bioactive mesoporous glass nanospheres (nanoMBGs) charged with antiosteoporotic drugs have great potential for the treatment of osteoporosis and fracture prevention. In this scenario, cells of the immune system are essential both in the development of disease and in their potential tostimulate therapeutic effects. In the present work, we hypothesize that nanoMBGs loaded with ipriflavone can exert a positive osteoimmune effect. With this objective, we assessed the effects of non-loaded and ipriflavone-loaded nanoparticles (nanoMBGs and nanoMBG-IPs, respectively) onCD4+ Th2 lymphocytes because this kind of cell is implicated in the inhibition of osseous loss by reducing the RANKL/OPG relationship through the secretion of cytokines. The results indicate that nanoMBGs enter efficiently in CD4+ Th2 lymphocytes, mainly through phagocytosis and clathrindependent mechanisms, without affecting the function of these T cells or inducing inflammatory mediators or oxidative stress, thus maintaining the reparative Th2 phenotype. Furthermore, the incorporation of the anti-osteoporotic drug ipriflavone reduces the potential unwanted inflammatory response by decreasing the presence of ROS and stimulating intracellular anti-inflammatory cytokine release like IL-4. These results evidenced that nanoMBG loaded with ipriflavone exerts a positive osteoimmune effect.
PB MDPI
YR 2023
FD 2023-07-26
LK https://hdl.handle.net/20.500.14352/106847
UL https://hdl.handle.net/20.500.14352/106847
LA eng
NO European Research Council
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 6 abr 2025