RT Journal Article
T1 Oral bioavailability, tissue distribution and depletion of flumequine in the food producing animal, chicken for fattening
A1 Anadón Navarro, Arturo Ramón
A1 Martínez Caballero, María Aranzazu
A1 Martínez Caballero, Marta
A1 De la Cruz, C
A1 Diaz, Manuel Jesús
A1 Martínez Larrañaga, María Rosa
AB Chickens were used to investigate kinetic properties including metabolism of flumequine after single IV and oral dose, and to study tissue depletion of flumequine after multiple oral doses. Plasma and tissue (muscle, kidney, liver and skin plus fat) concentrations of flumequine and its metabolite 7-hydroxyflumequine were determined using a HPLC method. After IV and oral administration (single-dose of 12 mg flumequine/kg bw), plasma concentration-time curves were best described by a two-compartment open model. Elimination half-life and mean residence time of flumequine in plasma were 6.91 and 5.90 h, respectively, after IV administration and 10.32 and 8.95 h after oral administration. Maximum plasma concentration was 3.62 microg/ml and interval from oral administration until maximum concentration was 1.43 h. Oral bioavailability was found to be 57%. Flumequine was converted to 7-hydroxyflumequine. After oral administration (24 mg/kg bw every 24 h for 5 days), renal and hepatic concentrations of flumequine (18-25 microg/kg) persisted for 4 days; however, at that time, flumequine residues were not detected in skin plus fat and muscle tissues. Flumequine administered at a dosage of 24 mg/kg bw every 24h for 5 days, with a withdrawal time of 2d ays, resulted in flumequine concentrations in target tissues that were less than the European Union maximal residue limits.
PB Elsevier
SN 0278-6915
YR 2008
FD 2008
LK https://hdl.handle.net/20.500.14352/98046
UL https://hdl.handle.net/20.500.14352/98046
LA eng
NO Anadón A, Martínez MA, Martínez M, De La Cruz C, Díaz MJ, Martínez-Larrañaga MR. Oral bioavailability, tissue distribution and depletion of flumequine in the food producing animal, chicken for fattening. Food Chem Toxicol. 2008 Feb;46(2):662-70. doi: 10.1016/j.fct.2007.09.086. Epub 2007 Sep 18. PMID: 17950971
NO Comisión Interministerial de Ciencia y Tecnología (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 10 abr 2025