TY - JOUR AU - Erasmus, Jennifer C. AU - Smolarczyk, Kasia AU - Brezovjakova, Helena AU - Mohd-Naim, Noor F. AU - Lozano Pérez, María Encarnación AU - Matter, Karl AU - Braga, Vania M.M. PY - 2021 DO - 10.1083/jcb.202002114 SN - 0021-9525 SN - 1540-8140 UR - https://hdl.handle.net/20.500.14352/96979 T2 - Journal of Cell Biology AB - Rac1 GTPase is hyperactivated in tumors and contributes to malignancy. Rac1 disruption of junctions requires its effector PAK1, but the precise mechanisms are unknown. Here, we show that E-cadherin is internalized via micropinocytosis in a... LA - eng M2 - e202002114 PB - Rockefeller University Press KW - Adhesion KW - Cancer KW - PAK KW - Cadherins TI - Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization TY - journal article VL - 220 ER -