RT Journal Article
T1 Preventing bacterial adhesion on scaffolds for bone tissue engineering
A1 Sánchez Salcedo, Sandra
A1 Colilla Nieto, Montserrat
A1 Izquierdo Barba, Isabel
A1 Vallet Regí, María Dulce Nombre
AB Bone implant infection constitutes a major sanitary concern which is associated to high morbidity and health costs. This manuscript focused on overviewing the main research efforts committed up to date to develop innovative alternatives to conventional treatments, such as those with antibiotics. These strategies mainly rely on chemical modifi-cations of the surface of biomaterials, such as providing it of zwitterionic nature, and tailoring the nanostructure surface of metal implants. These surface modifications have successfully allowed inhibition of bacterial adhesion, which is the first step to implant infection, and preventing long-term biofilm formation compared to pristine materials. These strate-gies could be easily applied to provide three-dimensional (3D) scaffolds based on bioceramics and metals, of which its manufacture using rapid prototyping techniques was reviewed. This opens the gates for the design and development of advanced 3D scaffolds for bone tissue engineering to prevent bone implant infections.Keywords: Antibacterial adhesion, biofilm formation, zwitterionic surfaces, nanostructured surfaces, rapid prototyping 3D scaffolds, bone tissue engineering.
PB Whioce Publishing Pte Ltd
SN 2424-8002
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/23075
UL https://hdl.handle.net/20.500.14352/23075
LA eng
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)	RESEARCHER ID N-4501-2014  (Sandra Sánchez Salcedo)ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo)
NO Ministerio de Economía y Competitividad (MINECO)
NO Agening Network of Excellence
DS Docta Complutense
RD 10 abr 2025