RT Journal Article
T1 Interaction between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers
A1 Nairi, Valentina
A1 Medda, Sara
A1 Piludu, Marco
A1 Casula, Maria Francesca
A1 Vallet Regí, María Dulce Nombre
A1 Monduzzi, Maura
A1 Salis, Andrea
AB Biomedical application of nanoparticles is largely associated to their fate in biological media which, in turn, is related to their surface properties. Surface functionalization plays a key role in determining biodegradation, cytotoxicity and biodistribution through interactions which may be mediated by the macromolecules occurring in biological media. A typical example is given by several proteins which lead to the formation of coated nanoparticles referred as protein corona. In this work we focus on mesoporous silica nanoparticles which, due to their intrinsic textural features, show potential as carriers for sustained drug release. Mesoporous silica nanoparticles functionalized by different biopolymers such as hyaluronic acid and chitosan were synthesized and characterized through small angle X-rays scattering, thermal analysis, and infrared spectroscopy. Biopolymer-coated mesoporous silica nanoparticles were used to investigate the interaction with bovine serum albumin, and to point out the role of different biopolymer coating. Gold-conjugated-bovine serum albumin was used to gain evidence on the occurrence of surface bound proteins enabling direct observation by transmission electron microscopy. Our findings provide insights on how different biopolymers affect the formation of a protein corona around functionalized mesoporous silica nanoparticles.
PB Elsevier
SN 1385-8947
YR 2018
FD 2018-01-03
LK https://hdl.handle.net/20.500.14352/11949
UL https://hdl.handle.net/20.500.14352/11949
LA eng
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. FP7
NO FIR 2017, RAS/FdS
DS Docta Complutense
RD 30 abr 2024