RT Journal Article T1 Moral decision-making in polysubstance dependent individuals A1 Carmona-Perera, Martina A1 Verdejo-García, Antonio A1 Young, Liane A1 Molina Fernández, Antonio Jesús A1 Pérez-García, Miguel AB Background Moral judgments depend on the integration of complex cognitive and emotional processes. Addiction is associated with core deficits in both cognitive and emotional processing, which may jointly lead to utilitarian biases in moral decision-making. Methods We assessed 32 polysubstance dependent males and 32 non-drug using controls using a previously validated moral judgment task, including non-moral scenarios, and moral dilemmas that were either high in emotional salience (“personal scenarios”) or low in emotional salience (“impersonal scenarios”).Results Polysubstance dependent individuals endorsed more utilitarian choices for personal dilemmas (e.g., smothering a baby to save a group of hidden people during wartime). These choices were also perceived as less difficult. Severity of alcohol use correlated with the proportion of utilitarian judgments.Conclusion Polysubstance dependent individuals show a more utilitarian pattern of moral decision-making for personal moral scenarios. PB Elsevier SN 0376-8716 YR 2012 FD 2012-06-08 LK https://hdl.handle.net/20.500.14352/97526 UL https://hdl.handle.net/20.500.14352/97526 LA eng NO Carmona-Perera, M., Verdejo-García, A., Young, L., Molina-Fernández, A., & Pérez-García, M. (2012). Moral decision-making in polysubstance dependent individuals. Drug and alcohol dependence, 126(3), 389–392. https://doi.org/10.1016/j.drugalcdep.2012.05.038 NO SEJ2006-08278, Spanish Ministry of Education and Science NO P07-HUM-03089, Andalusia Council of Science and Innovation (PI: Miguel Pérez-García) NO Grant COPERNICO, Plan Nacional sobre Drogas: Spanish Ministry of Health (PI: Antonio Verdejo-García) DS Docta Complutense RD 8 abr 2025