%0 Journal Article
%A Paris, Juan L.
%A Torre, Paz de la
%A Manzano, Miguel
%A Cabañas Criado, María Victoria
%A Flores, Ana I.
%A Vallet Regí, María Dulce Nombre
%T Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
%D 2016
%@ 1742-7061
%U https://hdl.handle.net/20.500.14352/23180
%X The potential use of human Decidua-derived mesenchymal stem cells (DMSCs) as a platform to carry mesoporous silica nanoparticles in cancer therapy has been investigated. Two types of nanoparticles were evaluated. The nanoparticles showed negligible toxicity to the cells, a fast uptake and a long retention inside them. Nanoparticle location in the cell was studied by colocalization with the lysosomes. Moreover, the in vitro and in vivo migration of DMSCs towards tumors was not modified by the evaluated nanoparticles. Finally, DMSCs transporting doxorubicin-loaded nanoparticles were capable of inducing cancer cell death in vitro.
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