RT Journal Article
T1 Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors
A1 Paris, Juan L.
A1 Torre, Paz de la
A1 Manzano, Miguel
A1 Cabañas Criado, María Victoria
A1 Flores, Ana I.
A1 Vallet Regí, María Dulce Nombre
AB The potential use of human Decidua-derived mesenchymal stem cells (DMSCs) as a platform to carry mesoporous silica nanoparticles in cancer therapy has been investigated. Two types of nanoparticles were evaluated. The nanoparticles showed negligible toxicity to the cells, a fast uptake and a long retention inside them. Nanoparticle location in the cell was studied by colocalization with the lysosomes. Moreover, the in vitro and in vivo migration of DMSCs towards tumors was not modified by the evaluated nanoparticles. Finally, DMSCs transporting doxorubicin-loaded nanoparticles were capable of inducing cancer cell death in vitro.
PB Elsevier
SN 1742-7061
YR 2016
FD 2016-03-15
LK https://hdl.handle.net/20.500.14352/23180
UL https://hdl.handle.net/20.500.14352/23180
LA spa
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID K-3719-2014 (Miguel Manzano García)ORCID 0000-0001-6238-6111 (Miguel Manzano García)RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado)ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
NO CIBER-BBN
NO Ageing Network of Excellence
NO Instituto de Salud Carlos III
NO MMA Foundation
NO Parkinson Madrid
NO Accion Estratégica en Salud
DS Docta Complutense
RD 1 may 2024