RT Journal Article
T1 Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration?
A1 Brackhan, Mirjam
A1 Arribas Blázquez, Marina
A1 Lastres-Becker, Isabel
AB Although the trigger for the neurodegenerative disease process is unknown, the relevance of aging stands out as a major risk for the development of neurodegeneration. In this review, we highlighted the relationship between the different cellular mechanisms that occur as a consequence of aging and transcription factor nuclear factor erythroid-2-related factor 2 (NRF2) and the connection with the TAU protein. We focused on the relevance of NRF2 in the main processes involved in neurodegeneration and associated with aging, such as genomic instability, protein degradation systems (proteasomes/autophagy), cellular senescence, and stem cell exhaustion, as well as inflammation. We also analyzed the effect of aging on TAU protein levels and its aggregation and spread process. Finally, we investigated the interconnection between NRF2 and TAU and the relevance of alterations in the NRF2 signaling pathway in both primary and secondary tauopathies. All these points highlight NRF2 as a possible therapeutic target for tauopathies.
PB MDPI
YR 2023
FD 2023-08-04
LK https://hdl.handle.net/20.500.14352/96822
UL https://hdl.handle.net/20.500.14352/96822
LA eng
NO Brackhan M, Arribas-Blazquez M, Lastres-Becker I. Aging, NRF2, and TAU: A Perfect Match for Neurodegeneration? Antioxidants (Basel). 2023 Aug 4;12(8):1564. doi: 10.3390/antiox12081564. PMID: 37627559; PMCID: PMC10451380.
NO Ministerio de Ciencia e Innovación, Spain (MINECO) (PID2019-105600RB-I00 to I.L.-B.)
NO Fundación Tatiana Pérez de Guzmán el Bueno (2021/00072/001 to I.L.-B.)
NO Biomedical Research Networking Center on Neurodegenerative Diseases ISCiii CIBERNED (CB06/05/0089 to I.L.-B.)
DS Docta Complutense
RD 6 abr 2025