RT Journal Article
T1 p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer
A1 Vega, Francisco Javier
A1 Caldés, Trinidad
A1 López, Jose Antonio
A1 Iniesta Serrano, María Pilar
A1 Sánchez Pernaute, Andrés
A1 Juan Chocano, María Del Carmen De
A1 Díaz-Rubio García, Eduardo
A1 Torres García, Antonio José
A1 Balibrea Cantero, José Luis
A1 Benito De Las Heras, Manuel R.
AB Inactivation of the tumour-suppressor gene p53 has been described as one of the most common molecular changes found in lung tumours. Our purpose was to study the prognostic value of p53 alterations and to determine whether some specific mutation type in the p53 gene could be associated with poor clinical evolution in non-small-cell lung cancer (NSCLC) patients. To this end, we studied 81 resected primary NSCLCs in order to detect p53 alterations. p53 protein accumulation was analysed using immunohistochemistry methods; p53 gene mutations in exons 5-9 were studied using polymerase chain reaction-single-strand conformation polymorphism and sequencing techniques. p53 protein was immunodetected in 46.9% of lung carcinomas and 44.7% of p53-immunopositive tumours showed p53 mutations. Survival analysis was performed on 62 patients. No survival differences were found for patients with or without p53 immunopositivity. A shorter survival was found in patients with underlying p53 gene mutations, mainly in patients with squamous cell lung tumours; the worst prognosis was found when mutations were located in exon 5 (P = 0.007). In conclusion, the location of p53 mutations might be considered as a prognostic indicator for the evaluation of poor clinical evolution in NSCLC patients.
PB SPRINGERNATURE
SN 0007-0920
YR 1997
FD 1997-07
LK https://hdl.handle.net/20.500.14352/116263
UL https://hdl.handle.net/20.500.14352/116263
LA eng
NO ega FJ, Iniesta P, Caldés T, Sanchez A, López JA, de Juan C, Diaz-Rubio E, Torres A, Balibrea JL, Benito M. p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer. Br J Cancer. 1997;76(1):44-51. doi: 10.1038/bjc.1997.334. PMID: 9218731; PMCID: PMC2223785.
DS Docta Complutense
RD 7 abr 2025